Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome. A multicenter randomized open trial
| Autor: | Giancarlo Parisi, Maurizio Pantalena, Giorgio Verdianelli, Gioacchino Leandro, M. Carrara, Gianni Tafner, Alessandra Faedo, Fabrizio Cardin, Marco Marino, Dario Goldin, Maurizio Zilli, Enrico Bottona |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Dietary Fiber Male medicine.medical_specialty Physiology Gastroenterology Galactans law.invention Irritable Bowel Syndrome Mannans Randomized controlled trial Quality of life law Internal medicine Plant Gums medicine Health Status Indicators Humans Irritable bowel syndrome Guar gum Dose-Response Relationship Drug business.industry Hepatology Middle Aged medicine.disease Treatment period Clinical trial Treatment Outcome Quality of Life Female Open label business Follow-Up Studies |
| Zdroj: | Digestive diseases and sciences. 50(6) |
| ISSN: | 0163-2116 |
| Popis: | The effects of partially hydrolyzed guar gum (PHGG) were compared in patients with irritable bowel syndrome, at 10 g/day (N = 40) and 5 g/day (N = 46) for 12 weeks. Gastrointestinal symptoms (GSRS), quality of life (SF-36), and psychological symptoms (HADS) were evaluated at baseline, during treatment (months 1 and 3), and at follow-up (month 6). In both groups symptoms and quality of life improved significantly after the first month of administration until follow-up compared to those at baseline. However, the improvement was significantly reduced at follow-up compared to the end of treatment. PHGG was effective for improving somatic (gastrointestinal symptoms) and psychological (quality of life and psychological distress) symptoms over the short term. Since the improvement tended to decrease after the end of the treatment period, further studies should evaluate the benefits of PHGG at a maintenance dosage. |
| Databáze: | OpenAIRE |
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