| Autor: |
Fan-Li Lin, Yu-Wen Cheng, Li-Huei Chen, Jau-Der Ho, Jing-Lun Yen, Mong-Heng Wang, Tzong-Huei Lee, George Hsiao |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Biomedicine & Pharmacotherapy. 158:114138 |
| ISSN: |
0753-3322 |
| DOI: |
10.1016/j.biopha.2022.114138 |
| Popis: |
Age-related macular degeneration (AMD) is the leading cause of low vision and blindness for which there is currently no cure. Increased matrix metalloproteinase-9 (MMP-9) was found in AMD and potently contributes to its pathogenesis. Resident microglia also promote the processes of chronic neuroinflammation, accelerating the progression of AMD. The present study investigates the effects and mechanisms of the natural compound theissenolactone B (LB53), isolated from Theissenia cinerea, on the effects of RPE dysregulation and microglia hyperactivation and its retinal protective ability in a sodium iodate (NaIO |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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