Posttraining but not pretraining lesions of the hippocampus interfere with feature-negative discrimination of fear-potentiated startle

light-). Conditioned fear to the target stimulus and feature-target compound were measured with fear-potentiated startle. Pre-training lesion of the hippocampus did not disrupt feature-negative discrimination performance relative to sham-operated and cortical lesioned controls. In contrast, hippocampal lesions performed after training severely disrupted performance. Specifically, rats with hippocampal lesions failed to inhibit fear when the noise feature was presented in compound with the target. However, these rats could reacquire the feature-negative discrimination. These observations suggest that the hippocampus may normally be involved in retention or retrieval of serial feature-negative discrimination; however, in its absence feature-negative discrimination can still be acquired. -->

ISSN:	1098-1063 1050-9631
DOI:	10.1002/hipo.10033
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352bbce1ae9f639eb716a5ba94f3e29f https://doi.org/10.1002/hipo.10033
Rights:	CLOSED
Přírůstkové číslo:	edsair.doi.dedup.....352bbce1ae9f639eb716a5ba94f3e29f
Autor:	William A. Falls, Scott A. Heldt, Gary D. Coover
Rok vydání:	2002
Předmět:	Male Reflex Startle Cognitive Neuroscience Neocortex Hippocampal formation Stimulus (physiology) Inhibitory postsynaptic potential Hippocampus Fear-potentiated startle Discrimination Learning Rats Sprague-Dawley Lesion Conditioning Psychological Neural Pathways Avoidance Learning medicine Animals Discrimination learning Memory Disorders Learning Disabilities Fear Startle reaction Rats medicine.anatomical_structure Acoustic Stimulation medicine.symptom Psychology Neuroscience Photic Stimulation
Zdroj:	Hippocampus. 12:774-786
ISSN:	1098-1063 1050-9631
DOI:	10.1002/hipo.10033
Popis:	Previous studies have suggested that the hippocampus may play an important role in some forms of inhibitory learning. The goal of the present study was to assess whether the hippocampus is also important for inhibition of fear acquired after serial feature-negative discrimination training. Rats were given aspiration lesions of the hippocampus either before or after training in which a target light was paired with shock when presented alone, but not paired with shock when presented in serial compound with a noise feature (light+/noise-->light-). Conditioned fear to the target stimulus and feature-target compound were measured with fear-potentiated startle. Pre-training lesion of the hippocampus did not disrupt feature-negative discrimination performance relative to sham-operated and cortical lesioned controls. In contrast, hippocampal lesions performed after training severely disrupted performance. Specifically, rats with hippocampal lesions failed to inhibit fear when the noise feature was presented in compound with the target. However, these rats could reacquire the feature-negative discrimination. These observations suggest that the hippocampus may normally be involved in retention or retrieval of serial feature-negative discrimination; however, in its absence feature-negative discrimination can still be acquired.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352bbce1ae9f639eb716a5ba94f3e29f https://doi.org/10.1002/hipo.10033 Zobrazit plný text záznamu Plný text