Short KIR Haplotypes in Pygmy Chimpanzee (Bonobo) Resemble the Conserved Framework of Diverse Human KIR Haplotypes

Autor: Lisbeth A. Guethlein, Benny P. Shum, Mei Hong, Erin J. Adams, Peter Parham, Raja Rajalingam
Jazyk: angličtina
Rok vydání: 2001
Předmět:
Male
Sequence Homology
Medical and Health Sciences
Conserved sequence
polymorphism
Receptors
KIR
Immunologic
immune system diseases
Complementary
Receptors
Immunology and Allergy
Receptors
Immunologic
Conserved Sequence
Phylogeny
Genetics
natural killer cells
biology
Bonobo
hemic and immune systems
KIR
Pedigree
Pan paniscus
Amino Acid
killer cell immunoglobulin-like receptors
Receptors
KIR2DL4
embryonic structures
Common chimpanzee
Original Article
Female
DNA
Complementary
Pan troglodytes
Immunology
Molecular Sequence Data
chemical and pharmacologic phenomena
Major histocompatibility complex
KIR2DL4
Species Specificity
Phylogenetics
biology.animal
evolution
otorhinolaryngologic diseases
Animals
Humans
Amino Acid Sequence
DNA Primers
Base Sequence
Sequence Homology
Amino Acid
Haplotype
Genetic Variation
DNA
biology.organism_classification
recombination
Haplotypes
biology.protein
Zdroj: The Journal of Experimental Medicine
The Journal of experimental medicine, vol 193, iss 1
ISSN: 1540-9538
0022-1007
Popis: Some pygmy chimpanzees (also called Bonobos) give much simpler patterns of hybridization on Southern blotting with killer cell immunoglobulin-like receptor (KIR) cDNA probes than do either humans or common chimpanzees. Characterization of KIRs from pygmy chimpanzees having simple and complex banding patterns identified nine different KIRs, representing seven genes. Five of these genes have orthologs in the common chimpanzee, and three of them (KIRCI, KIR2DL4, and KIR2DL5) also have human orthologs. The remaining two genes are KIR3D paralogous to the human and common chimpanzee major histocompatibility complex A– and/or -B–specific KIRs. Within a pygmy chimpanzee family, KIR haplotypes were defined. Simple patterns on Southern blot were due to inheritance of “short” KIR haplotypes containing only three KIR genes, KIRCI, KIR2DL4, and KIR3D, each of which represents one of the three major KIR lineages. These three genes in pygmy chimpanzees or their corresponding genes in humans and common chimpanzees form the conserved “framework” common to all KIR haplotypes in these species and upon which haplotypic diversity is built. The fecundity and health of individual pygmy chimpanzees who are homozygotes for short KIR haplotypes attest to the viability of short KIR haplotypes, indicating that they can provide minimal, essential KIRs for the natural killer and T cells of the hominoid immune system.
Databáze: OpenAIRE
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