Comparison of radioligand assay and immunostaining for epidermal growth factor receptor in human breast cancer
| Autor: | P.V. Newcomb, D J Hastrich, J. R. Farndon, J M Dunn, S Nicholson |
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| Rok vydání: | 1994 |
| Předmět: |
Receptor Status
Pathology medicine.medical_specialty Mammary gland Breast Neoplasms Sensitivity and Specificity Immunoenzyme Techniques Radioligand Assay Breast cancer Predictive Value of Tests Epidermal growth factor Biomarkers Tumor medicine Humans Epidermal growth factor receptor biology business.industry Cancer medicine.disease ErbB Receptors medicine.anatomical_structure Cancer research biology.protein Immunohistochemistry Female Surgery business |
| Zdroj: | British Journal of Surgery. 81:853-855 |
| ISSN: | 1365-2168 0007-1323 |
| DOI: | 10.1002/bjs.1800810620 |
| Popis: | Epidermal growth factor (EGF) receptor status is a useful prognostic indicator in women with breast cancer. Lack of standardization and correlation of methodology for the detection of EGF receptor has hampered its further evaluation. EGF receptor status was ascertained by immunohistochemistry and radioligand assay in 120 breast cancers. Of 52 tumours negative for EGF receptor on radioligand assay, 47 were negative on immunohistochemistry and, of 68 tumours positive for the receptor on assay, 52 were positive on immunohistochemistry. If the more widely evaluated radioligand assay is assumed to be the ‘gold standard’, immunohistochemistry has a sensitivity of 81 per cent and a specificity of 91 per cent. |
| Databáze: | OpenAIRE |
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