A novel unembalmed human cadaveric limb model for assessing conformational changes in self-expanding nitinol stents in the popliteal artery

Autor: Karthik Vamanan, Kamal Gupta, Mariam Vanderhyde, Reza Masoomi, Lorin P. Maletsky, Eric Shurtleff, Pamela Thomas, Fallon Fitzwater
Rok vydání: 2018
Předmět:
Nitinol stent
Knee Joint
medicine.medical_treatment
Knee flexion
Self Expandable Metallic Stents
Strain (injury)
030204 cardiovascular system & hematology
Prosthesis Design
03 medical and health sciences
0302 clinical medicine
Cadaver
Axial compression
medicine.artery
Materials Testing
medicine
Humans
Popliteal Artery
Radiology
Nuclear Medicine and imaging
cardiovascular diseases
030212 general & internal medicine
Range of Motion
Articular
Aged
Aged
80 and over
Terpenes
business.industry
Endovascular Procedures
Stent
General Medicine
Middle Aged
equipment and supplies
medicine.disease
Popliteal artery
Prosthesis Failure
Equipment Failure Analysis
surgical procedures
operative
Feasibility Studies
Stress
Mechanical
Cardiology and Cardiovascular Medicine
Cadaveric spasm
business
Nuclear medicine
Zdroj: Catheterization and Cardiovascular Interventions. 93:113-119
ISSN: 1522-1946
Popis: Objective To develop an unembalmed human cadaveric lower limb model as a more realistic environment for testing self-expanding nitinol stents. We studied conformational changes and strain induced by knee flexion in nitinol stents deployed in the popliteal artery (PA). Methods One Lifestent® each was deployed into one limb of four cadavers (control group), while the contralateral leg received a different stent (Absolute®, Protege Everflex®, Supera®, and Gore Viabahn®). The limbs were mounted on a quasi-static knee rig (QKR) and X-ray imaging was performed at pre-defined knee flexion angles. A least-squares solution to the equation of a circle was used to assess radius of curvature at flexion points (FP), and nominal strain was calculated for each stented artery. Results There were differences but also some similarities in conformational changes seen in the various stents. Knee flexion produced at least two FP in all stents. The mean radius of curvature decreased with increasing degrees of flexion but more so in distal (main) than proximal (accessory) FP (22 mm vs. 11 mm) in all stents. Supera® stent had the greatest relative radii of curvatures, and Absolute® stent had the highest strain value in comparison to the contralateral PA as the control group. Conclusion This study describes a novel human cadaveric limb model for testing self-expanding nitinol stents implanted in the PA. Several parameters of conformational change in the stented PA such as FP formation, FP translocation and strain induced by axial compression were described. These may be useful for developing new stents for the PA location.
Databáze: OpenAIRE
Externí odkaz: