Reduced sensitivity to beta-adrenergic agonists in Basenji-Greyhound dogs
| Autor: | Carol A. Hirshman, Joseph D. Tobias, R A Sauder |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Physiology Bronchoconstriction Histamine Antagonists Pulmonary compliance chemistry.chemical_compound Catecholamines Dogs Theophylline Physiology (medical) Internal medicine medicine Animals Methacholine Compounds Albuterol Lung Compliance Aerosols Dose-Response Relationship Drug business.industry Airway Resistance Adrenergic beta-Agonists Aminophylline Endocrinology chemistry Salbutamol Methacholine medicine.symptom business Histamine medicine.drug |
| Zdroj: | Journal of Applied Physiology. 69:1212-1219 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1990.69.4.1212 |
| Popis: | To investigate the inhibitory effects of beta-adrenergic agonists and aminophylline on pulmonary responsiveness, we evaluated the ability of albuterol and aminophylline to attenuate pulmonary responses to aerosol challenge with methacholine and histamine in intact Basenji-Greyhound (BG) and selected mongrel dogs. Pulmonary responses were measured in untreated dogs and in dogs pretreated with albuterol (1 and 2.5 micrograms/kg) or aminophylline. Before aerosol challenge, baseline pulmonary resistance (RL) and dynamic compliance (Cdyn) were not significantly different between the BGs and the mongrels. In the untreated dogs, pulmonary responses to methacholine and histamine aerosols were not different between the BGs and the mongrels. Pretreatment with albuterol (1 microgram/kg) or aminophylline significantly attenuated the pulmonary response to methacholine in the mongrels but was without effect in the BGs. Albuterol (2.5 micrograms/kg) significantly attenuated the pulmonary response to methacholine in the BGs and the mongrels; however, this attenuation was significantly greater (P less than 0.05) in the mongrels than in the BGs. In response to histamine challenge, no differences were seen between the BGs and the mongrels in the control state (no pretreatment) or after pretreatment with albuterol or aminophylline. This study demonstrates that in BGs pulmonary responsiveness to methacholine but not histamine is resistant to inhibition by beta-adrenergic agonists. This may result from a qualitative or quantitative defect in either the cholinergic or beta-adrenergic receptor or to an abnormality distal to the receptors in the signal transduction mechanism at a site where the two signals interact. |
| Databáze: | OpenAIRE |
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