Sex Differences in the Relation Between Subjective Memory Complaints, Impairments in Instrumental Activities of Daily Living, and Risk of Dementia
| Autor: | Herrer Abdulrahman, Eric P. Moll van Charante, Jan Willem van Dalen, Willem A. van Gool, Edo Richard |
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| Přispěvatelé: | Neurology, Public and occupational health, 10 Public Health & Methodologie, APH - Mental Health, APH - Methodology, APH - Aging & Later Life, Amsterdam Neuroscience - Neurodegeneration, General practice, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, ACS - Diabetes & metabolism |
| Rok vydání: | 2022 |
| Předmět: |
Male
Activities of daily living Epidemiology Instrumental Activities of Daily Living Subjective memory Neuropsychological Tests Competing risks Cellular and Molecular Neuroscience All institutes and research themes of the Radboud University Medical Center Developmental Neuroscience Risk Factors mental disorders Activities of Daily Living medicine Risk of mortality Dementia sex Humans Cognitive Dysfunction Aged Proportional Hazards Models Memory Disorders Sex Characteristics subjective memory complaints business.industry Proportional hazards model General Neuroscience Health Policy General Medicine Alzheimer's disease Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] medicine.disease Clinical Psychology Psychiatry and Mental health Increased risk Geriatric Depression Scale Female Independent Living Neurology (clinical) Geriatrics and Gerontology business Mental Status Schedule human activities Demography |
| Zdroj: | Journal of Alzheimer's Disease, 85, 283-294 Journal of Alzheimer's Disease, 85(1), 283-294. IOS Press Journal of Alzheimer's Disease, 85, 1, pp. 283-294 |
| ISSN: | 1387-2877 |
| Popis: | Background: Older people with subjective memory complaints (SMC) and Instrumental Activities of Daily Living impairments (IADL-I) have an increased risk of developing dementia. Previous reports suggest that the predictive value of SMC and IADL-I may differ between sexes, leaving possible consequences for personalized risk prediction and prognosis. However, none of these studies addressed the competing risk of death, which may substantially differ between sexes. Objective: We investigated sex-differences in the association between IADL-I, SMC, and incident dementia and mortality as competing risk. Methods: 3,409 community-dwelling older people without dementia (mean age 74.3±2.5), were followed for 6.7 years (median). Baseline SMC were assessed using the 15-item Geriatric Depression Scale memory question, and IADL-I using the Academic Medical Center Linear Disability Score. Potential sex-differences in the predictive value of SMC and IADL-I were assessed using Cox regression models with an interaction term for sex. Results: HRs for isolated SMC and SMC + IADL-I and risk of dementia were higher in women (HR: 2.02, 95% CI = 0.91–4.46, p = 0.08; HR:2.85, 95% CI = 1.65–4.91, p |
| Databáze: | OpenAIRE |
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