MiR-320a as a Potential Novel Circulating Biomarker of Arrhythmogenic CardioMyopathy
| Autor: | Daniela Riggio, Giulio Pompilio, Mauro Giacca, Valentina Catto, Michela Casella, Elena Sommariva, Silvia Moimas, Claudio Tondo, Corrado Carbucicchio, Gianfranco Sinagra, Fabio Cattaneo, Ilaria Stadiotti, Maria Teresa Sandri, Floriana Maria Farina, Manuela Muratori, Andrea Barbuti, Mattia Chiesa, Gualtiero I. Colombo, Antonio Russo, Matteo Dal Ferro, Gianluca Vernillo, Giulia Vettor, Yuri D'Alessandra, Silvia Brambilla |
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| Přispěvatelé: | Sommariva, Elena, D'Alessandra, Yuri, Farina, Floriana Maria, Casella, Michela, Cattaneo, Fabio, Catto, Valentina, Chiesa, Mattia, Stadiotti, Ilaria, Brambilla, Silvia, Dello Russo, Antonio, Carbucicchio, Corrado, Vettor, Giulia, Riggio, Daniela, Sandri, Maria Teresa, Barbuti, Andrea, Vernillo, Gianluca, Muratori, Manuela, Dal Ferro, Matteo, Sinagra, Gianfranco, Moimas, Silvia, Giacca, Mauro, Colombo, Gualtiero Ivanoe, Pompilio, Giulio, Tondo, Claudio |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty Science Cardiomyopathy 030204 cardiovascular system & hematology Ventricular tachycardia Bioinformatics Severity of Illness Index Article Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Text mining Internal medicine Severity of illness Medicine Humans Arrhythmogenic Right Ventricular Dysplasia Multidisciplinary business.industry Case-control study arrhythmogenic cardiomyopathy Middle Aged medicine.disease miR-320a Arrhythmogenic right ventricular dysplasia Circulating MicroRNA MicroRNAs 030104 developmental biology ROC Curve Case-Control Studies Tachycardia Ventricular Female Differential diagnosis biomarkers business Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
| ISSN: | 2045-2322 |
| Popis: | Diagnosis of Arrhythmogenic CardioMyopathy (ACM) is challenging and often late after disease onset. No circulating biomarkers are available to date. Given their involvement in several cardiovascular diseases, plasma microRNAs warranted investigation as potential non-invasive diagnostic tools in ACM. We sought to identify circulating microRNAs differentially expressed in ACM with respect to Healthy Controls (HC) and Idiopathic Ventricular Tachycardia patients (IVT), often in differential diagnosis. ACM and HC subjects were screened for plasmatic expression of 377 microRNAs and validation was performed in 36 ACM, 53 HC, 21 IVT. Variable importance in data partition was estimated through Random Forest analysis and accuracy by Receiver Operating Curves. Plasmatic miR-320a showed 0.53 ± 0.04 fold expression difference in ACM vs. HC (p |
| Databáze: | OpenAIRE |
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