Lepidopteran species have a variety of defence strategies against bacterial infections
| Autor: | Franziska Dickel, Johanna Mappes, Lauri Mikonranta, Dalial Freitak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
6-Tox immune priming 030106 microbiology Virulence Microbiology resistance 03 medical and health sciences Immune system Species Specificity Immunity isovahakoisa Animals immuniteetti geeniekspressio Arctia plantaginis Pathogen Defensin Ecology Evolution Behavior and Systematics Serratia marcescens Cecropin Innate immune system tolerance biology fungi bacterial infection virulenssi biology.organism_classification immunity extracellular protease Lepidoptera virulence Galleria mellonella 030104 developmental biology Host-Pathogen Interactions gene expression ta1181 |
| Popis: | The insect immune system has versatile ways of coping with microbial insults. Currently, innate immune priming has been described in several invertebrates, and the first insights into its mechanistic basis have been described. Here we studied infections with two different strains of Serratia marcescens bacteria in two different Lepidopteran hosts. The results reveal fundamental differences between the two hosts, a well-known model organism Galleria mellonella and a non-model species Arctia plantaginis. They differ in their strategies for resisting oral infections; priming their defences against a recurring sepsis; and upregulating immunity related genes as a response to the specific pathogen strains. The two bacterial strains (an environmental isolate and an entomopathogenic isolate) differ in their virulence, use of extracellular proteases, survival in the larval gut, and in the immune response they evoke in the hosts. This study explores the potential mechanistic explanations for both host and pathogen specific characters that significantly affect the outcome of Gram-negative bacterial infection in Lepidopteran larvae. The results highlight the need to pay greater attention to the differences between model and non-model hosts, and closely related pathogen strains, in immunological studies. peerReviewed |
| Databáze: | OpenAIRE |
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