Preliminary study on anti‐Müllerian hormone, antral follicle count, menstruation and lymphocyte subsets in systemic lupus erythematosus patients

Autor: Ehab F. Girbash, Shaimaa M. Abdelwahab, Dalia S. Fahmi, Hussein M. Abdeldayem, Rania Ghonaim, Doaa S. Atta
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Gynecology & Obstetrics. 159:129-135
ISSN: 1879-3479
0020-7292
Popis: To investigate whether systemic lupus erythematosus (SLE) has a negative impact on the fertility of young women of reproductive age through SLE activity and therapy.This retrospective case-control study was conducted in 50 patients with SLE and 50 healthy controls who fulfilled the 1997 American College of Rheumatology criteria. Anti-Müllerian hormone (AMH) levels were measured, and ovarian volume (OV) and total antral follicle count (AFC) were assessed by transvaginal sonar in patients and in healthy controls. Analysis was carried out on the association of SLE disease activity with AMH, OV, and AFC.SLE patients had decreased levels of AMH, OV, and AFC, correlating with age, activity, and damage levels of SLE, displaying a negative consequence of SLE. In the SLE group, the CD4AMH levels and AFC were decreased in women with SLE with autoimmune activity and CD8
Databáze: OpenAIRE
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