Inhibitory effects of isradipine on uterine contractions in pregnant rats
| Autor: | Mehmet Nalbant, Selim Kutlu, Selahattin Kumru, Mete Ozcan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Isradipine Chemistry medicine.drug_class Myometrium Prostaglandin chemistry.chemical_element General Medicine Calcium channel blocker Calcium Inhibitory postsynaptic potential chemistry.chemical_compound Endocrinology Oxytocin Internal medicine medicine Gestation medicine.drug |
| Zdroj: | Perinatal Journal. 23:158-164 |
| ISSN: | 1305-3124 |
| DOI: | 10.2399/prn.15.0233004 |
| Popis: | Objective: To investigate the effects of isradipine, which is a calcium channel blocker, on late pregnant rats’ myometrium under in vitro conditions. Methods: Stripes were obtained from the myometriums of pregnant rats which were decapitated on the 18 days of gestation. The effects of isradipine on myometrium were investigated in four groups and four cumulative doses: 1 ng/ml, 10 ng/ml, 0.1 μg/ml, 1 μg/ml. Group 1: spontaneous myometrial contractions, Group II: myometrial contractions induced by oxytocin, Group III: myometrial contractions induced by prostaglandin, Group IV: myometrial contractions induced by oxytocin in calcium-free medium. Wilcoxon signed ranks test was used for the statistical analysis and p |
| Databáze: | OpenAIRE |
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