Relationship of Incorporation of Radioprecursors into Protein and Phospholipids of the Plasmalemma of Guinea Pig (Neonate) Intestinal Epithelium and the Cessation of Uptake of Macromolecules (Closure)
| Autor: | J.O. Rundell, J.G. Lecce |
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| Rok vydání: | 1978 |
| Předmět: |
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Macromolecular Substances Guinea Pigs Absorption (skin) Biology Endocytosis Epithelium Phosphates Guinea pig Leucine Intestine Small medicine Animals Phospholipids Microvilli Pinocytosis Cell Membrane Age Factors Proteins Intestinal epithelium medicine.anatomical_structure Animals Newborn Intestinal Absorption Biochemistry Isotope Labeling Protein Biosynthesis Pediatrics Perinatology and Child Health Specific activity gamma-Globulins Phosphorus Radioisotopes Developmental Biology |
| Zdroj: | Neonatology. 34:278-285 |
| ISSN: | 1661-7819 1661-7800 |
| DOI: | 10.1159/000241141 |
| Popis: | The incorporation of radioprecursors into intestinal epithelial cell proteins and phospholipids was studied to assess the role of protein and phospholipid synthesis and/or turnover in the cessation of the absorption of macromolecules (closure). Radiophosphorus incorporation into cellular phospholipids was enhanced when pinocytosis was stimulated. The specific activity of cellular and brush border phospholipids and specific phosphatides increased during the period of active endocytosis. No alteration in specific phosphatide percent composition was observed. Radioamino acid incorporation into cellular protein was not influenced by age. These data are consistent with the idea that the period of active macromolecule absorption by the guinea pig intestinal epithelium is defined by the exhaustion of membrane available for endocytosis. |
| Databáze: | OpenAIRE |
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