3He-MRI-based measurements of intrapulmonarypO2 and its time course during apnea in healthy volunteers: first results, reproducibility, and technical limitations

Autor:	Wolfgang Schreiber, Gorden Hanisch, Balthasar Eberle, Norbert Weiler, Werner Heil, Klaus Markstaller, T. Grossmann, Hans-Ulrich Kauczor, Ernst W. Otten, Anselm Deninger, Michael Ebert, Reinhard Surkau
Rok vydání:	2000
Předmět:	Reproducibility medicine.diagnostic_test Chemistry Apnea Magnetic resonance imaging Nuclear magnetic resonance Time course Healthy volunteers medicine Molecular Medicine Radiology Nuclear Medicine and imaging medicine.symptom Spectroscopy Regional differences Lung function Acquisition technique
Zdroj:	NMR in Biomedicine. 13:194-201
ISSN:	1099-1492 0952-3480
DOI:	10.1002/1099-1492(200006)13:4<194::aid-nbm643>3.0.co;2-d
Popis:	We applied a recently developed method of following the time course of the intrapulmonary oxygen partial pressure p(O2)(t) during apnea by (3)He MRI to healthy volunteers. Using two imaging series with different interscan times during two breathholds (double acquisition technique), relaxation of (3)He due to paramagnetic oxygen and depolarization by RF pulses were discriminated. In all four subjects, the temporal evolution of p(O2) was found to be linear, and was described by an initial partial pressure p(0) and a decrease rate R. Also, regional differences of both p(0) and R were observed. A correlation between p(0) and R was apparent. Finally, we discuss limitations of the double acquisition approach.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35163eaf9ab60086ffb5c0c0a79f06ec https://doi.org/10.1002/1099-1492(200006)13:4<194::aid-nbm643>3.0.co Zobrazit plný text záznamu Plný text