1.1 DIASTOLIC LEFT VENTRICULAR FUNCTION IN RELATION TO CIRCULATING METABOLIC BIOMARKERS IN A GENERAL POPULATION
| Autor: | Wen-Yi Yang, Lotte Jacobs, Josep Redon, Fang Fei Wei, Tim S. Nawrot, Zhenyu Zhang, Jan A. Staessen, Lutgarde Thijs, Peter Verhamme, Vannina G. Marrachelli, Tatiana Kuznetsova, Jens-Uwe Voigt, Daniel Monleon |
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| Rok vydání: | 2015 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Creatinine business.industry Metabolite Prohormone Population Diastole Area under the curve Specialties of internal medicine General Medicine Brain natriuretic peptide Glutamine chemistry.chemical_compound Endocrinology RC581-951 chemistry RC666-701 Internal medicine medicine Diseases of the circulatory (Cardiovascular) system business education medicine.drug |
| Zdroj: | Artery Research, Vol 12 (2015) |
| ISSN: | 1876-4401 |
| Popis: | Background The metabolic signature associated with subclinical diastolic left ventricular (LV) dysfunction in the population remains ill defined. Methods and Results In 711 randomly recruited Flemish (50.8% women; mean age, 50.8 years), we assessed echocardiographic Doppler indexes of diastolic LV function in relation to 44 circulating metabolites determined by nuclear magnetic resonance spectroscopy. In multivariable‐adjusted regression analysis with Bonferroni correction of significance levels applied, peak a’ decreased ( P ≤0.048) and e’/a’ increased ( P ≤0.044) with circulating tyrosine, high‐density lipoprotein apolipoproteins, glucose+glutamine, and an unidentified molecule. Effect sizes expressed per 1‐SD increment in the metabolite ranged from −0.277 to −0.203 cm/s for peak a’ and from +0.047 to +0.054 for e’/a’. In addition, peak a’ decreased ( P ≤0.031) with glucose+2‐aminobutyrate (−0.261 cm/s) and glucose+2‐phosphoglycerate (−0.209 cm/s). In partial least square discriminant analysis (PLS‐DA), metabolites associated with normal diastolic LV function (n=538) included glucose+glutamine, glucose+2‐aminobutyrate, and glucose+2‐phosphoglycerate, whereas those siding with abnormal function encompassed 4‐aminobutyrate, 4‐hydroxybutyrate, creatinine, and phosphocholine. In receiver operating characteristics plots, adding 3 latent factors identified by PLS‐DA to prohormone brain natriuretic peptide increased ( P |
| Databáze: | OpenAIRE |
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