Clinical characteristics and leptomeningeal collateral status in pediatric and adult patients with ischemic moyamoya disease

Autor: Qian Zhang, Sijie Li, Cong Han, Xiang-Yang Bao, Zhiwen Liu, Hui Wang, Zheng-Shan Zhang, Lian Duan
Rok vydání: 2019
Předmět:
Adult
Brain Infarction
0301 basic medicine
medicine.medical_specialty
Adolescent
Collateral Circulation
Infarction
Retrograde Flow
Posterior cerebral artery
Neurosurgical Procedures
Brain Ischemia
03 medical and health sciences
Meninges
0302 clinical medicine
Physiology (medical)
medicine.artery
Internal medicine
Humans
Medicine
Pharmacology (medical)
Moyamoya disease
Stage (cooking)
Child
Letters to the Editor
Letter to the Editor
Retrospective Studies
Posterior Cerebral Artery
Pharmacology
Adult patients
medicine.diagnostic_test
business.industry
Advanced stage
Angiography
Digital Subtraction
Digital subtraction angiography
Middle Aged
medicine.disease
Psychiatry and Mental health
Treatment Outcome
030104 developmental biology
Ischemic Attack
Transient
Child
Preschool
Moyamoya Disease
business
030217 neurology & neurosurgery
Zdroj: CNS Neuroscience & Therapeutics
ISSN: 1755-5949
1755-5930
DOI: 10.1111/cns.13130
Popis: AIM Previous studies have found significant differences in clinical characteristics between pediatric and adult moyamoya disease (MMD) patients, but few studies have focused on the factors underlying these differences. We aimed to investigate the differences in leptomeningeal collateral (LMC) status between pediatric and adult MMD patients and to analyze the effects of LMCs on clinical characteristics and therapeutic prognosis. METHODS We retrospectively analyzed 214 MMD patients from January 2014 to January 2016. Clinical characteristics and LMC status were compared between the pediatric and adult patients. LMC status was graded as good or poor depending on the retrograde flow from the posterior cerebral artery (PCA) on digital subtraction angiography (DSA). RESULTS A total of 83 pediatric and 131 adult (1:1.6) MMD patients were analyzed. Pediatric patients were more likely to experience a transient ischemic attack (81%), whereas adult patients were more likely to experience infarction (51%). Regarding the different MMD stages (the early, medium, and advanced stages corresponded to Suzuki stages 1-2, 3-4, and 5-6, respectively), the prevalence of good LMC status was higher for pediatric patients than for adult patients in the early stage (P = 0.047) and the medium stage (P = 0.001), but there were no differences between these patient groups in the advanced stage (P = 0.547). Worse postoperative angiographic outcomes (P = 0.017) were found in adult patients than in pediatric patients in the medium stage. Poor LMC status had strong correlations with infarction (P
Databáze: OpenAIRE
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