Induction of p53-dependent apoptosis in vivo by nedaplatin and ionizing radiation
| Autor: | Norio Mitsuhashi, Hideo Niibe, Yuji Nakamura, Yoshiyuki Suzuki, Kazushige Hayakawa, Michitaka Yamakawa, Sachiko Nasu, Minoru Hasegawa, Masana Matsuura |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Cancer Research
Programmed cell death Organoplatinum Compounds medicine.medical_treatment Transplantation Heterologous Mice Nude Antineoplastic Agents Apoptosis Biology Ionizing radiation Mice chemistry.chemical_compound In vivo medicine Animals Humans Neuroectodermal Tumors Primitive Nedaplatin Cisplatin Chemotherapy Brain Neoplasms General Medicine Combined Modality Therapy Radiation therapy Oncology chemistry Cancer research Tumor Suppressor Protein p53 Neoplasm Transplantation medicine.drug |
| Zdroj: | Oncology Reports. |
| ISSN: | 1791-2431 1021-335X |
| Popis: | p53 protein expression, apoptosis and growth delay induced by nedaplatin, a novel platinum compound, were investigated in vivo, and compared with those induced by ionizing radiation. A human ependymoblastoma with wild-type p53 was transplanted subcutaneously to the thighs of nude mice. The incidences of p53 protein-positive cells and apoptosis in tumors increased following exposure to ionizing radiation. In tumors treated with nedaplatin, they also increased, but the incidences of p53 protein-positive cells and apoptosis induced by 32 mg/kg nedaplatin, 1/2 LD50, were lower than those induced by 1 Gy irradiation. However, growth-delay assay showed no significant difference between the efficacy of 32 mg/kg nedaplatin and that of 1 Gy irradiation. These results suggest that the main antineoplastic activity caused by nedaplatin may be mediated through different mechanisms than those of the p53-dependent early apoptosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|