Genomic analysis of a case of multifocal adenocarcinoma in ulcerative colitis
| Autor: | Ronald van Marion, Josiane C. Wink, Herman van Dekken, Monique M. C. P. Hoogmans, Kees J. Vissers, Ernst J. Kuipers, C. Janneke van der Woude, Winand N.M. Dinjens, Patrick Franken, W. Ruud Schouten |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Pathology Clone (cell biology) Adenocarcinoma Biology Pathology and Forensic Medicine medicine Humans Colitis Molecular Biology Aged Aged 80 and over Chromosome Aberrations Nucleic Acid Hybridization Anatomical pathology Cell Biology General Medicine medicine.disease Ulcerative colitis Dysplasia Colonic Neoplasms Colitis Ulcerative Female Microsatellite Instability Field cancerization Comparative genomic hybridization |
| Zdroj: | Virchows Archiv. 449:716-721 |
| ISSN: | 1432-2307 0945-6317 |
| Popis: | Long-standing ulcerative colitis is associated with an elevated risk of developing colonic adenocarcinoma. A very limited group of patients present with multiple synchronous cancers. This could be due to either a multifocal presentation of the same neoplastic clone or different tumors arising in a large area of polyclonal dysplastic colonic mucosa ("field cancerization"). Here, we describe a patient with long-standing colitis and three different tumors in the rectosigmoid part of the large bowel. Clonal evaluation of the lesions was performed by array-based comparative genomic hybridization. These three neoplasms showed a comparable pattern of genomic alterations characterized by gains of chromosomes 12, 13, and 20. Noteworthy, dysplastic mucosa distal to the three cancers displayed a completely different pattern of genomic changes indicating that different cell lineages were present. In addition, all three carcinomas were microsatellite stable and revealed identical immunoprofiles for several cancer-associated genes. We conclude that these three multifocal tumors must have originated from the same preneoplastic lineage. |
| Databáze: | OpenAIRE |
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