The galanin receptor-3 antagonist, SNAP 37889, inhibits cue-induced reinstatement of alcohol-seeking and increases c-Fos expression in the nucleus accumbens shell of alcohol-preferring rats
| Autor: | Elvan Djouma, Matthew W. Hale, Spencer J. Williams, Adam J. Lawther, Sigrid Limburg, Kira-Elise Wilson, Andrew J Lawrence, Melissa K Duggan |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Indoles Lateral hypothalamus medicine.drug_class Drug-Seeking Behavior Prefrontal Cortex Self Administration Nucleus accumbens Nucleus Accumbens Extinction Psychological 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Pharmacology (medical) Galanin Pharmacology Behavior Animal Ethanol Chemistry Ventral Tegmental Area Antagonist Receptor Galanin Type 3 Receptor antagonist Rats Ventral tegmental area Alcoholism Psychiatry and Mental health 030104 developmental biology Endocrinology medicine.anatomical_structure Cues Self-administration Proto-Oncogene Proteins c-fos Galanin receptor 3 030217 neurology & neurosurgery |
| Zdroj: | Journal of Psychopharmacology. 32:911-921 |
| ISSN: | 1461-7285 0269-8811 |
| DOI: | 10.1177/0269881118780015 |
| Popis: | Introduction: This study aimed to investigate the effects of the galanin-3 receptor antagonist, SNAP 37889, on c-Fos protein expression after cue-induced reinstatement of alcohol-seeking in the brains of alcohol-preferring rats. Methods: Eighteen alcohol-preferring rats were trained to self-administer 10% v/v ethanol in the presence of response-contingent cues, which was followed by extinction. Rats were then treated with SNAP 37889 (30 mg/kg, i.p.) or vehicle, before being tested for cue-induced reinstatement. Administration of SNAP 37889 reduced cue-induced reinstatement of ethanol-seeking behaviour. To examine the effect of SNAP 37889 and cue-induced reinstatement on neuronal activation, c-Fos expression was measured in subregions of the medial prefrontal cortex and nucleus accumbens. Results: SNAP 37889 administration increased c-Fos immunoreactivity in the nucleus accumbens shell, but was without effect in the nucleus accumbens core and the medial prefrontal cortex. Dual-label Fos/tyrosine hydroxylase immunohistochemistry was used to examine the effects of SNAP 37889 on dopamine neurons in the ventral tegmental area; however, no differences between SNAP 37889 and vehicle-treated rats were found. Conclusions: These data support previous findings of galanin-3 receptor involvement in cue-induced reinstatement of alcohol-seeking behaviour, and provide novel evidence that the ability of galanin-3 receptor antagonism to attenuate cue-induced reinstatement relates to activation of the nucleus accumbens shell. |
| Databáze: | OpenAIRE |
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