Effects of hypothermia and hyperthermia on attentional and spatial learning deficits following neonatal hypoxia-ischemic insult in rats
| Autor: | Tsuyomu Ikenoue, Michihiro Fujiwara, Katsunori Iwasaki, Tetsuya Yoshikawa, Kenichi Mishima, Yi X. Xia, Nobuaki Egashira, Naoya Aoo, Tomoaki Ikeda |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Hyperthermia Fever Thalamus Ischemia Spatial Behavior Posterior parietal cortex Hypothermia Striatum Water maze Choice Behavior Behavioral Neuroscience Pregnancy Reaction Time medicine Animals Analysis of Variance Memory Disorders Behavior Animal Brain Hypoxia (medical) medicine.disease Rats Animals Newborn Attention Deficit Disorder with Hyperactivity Anesthesia Hypoxia-Ischemia Brain Female medicine.symptom Psychology Neuroscience |
| Zdroj: | Behavioural Brain Research. 151:209-217 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2003.08.018 |
| Popis: | We previously reported that rats exposed to neonatal hypoxic-ischemic (HI) insult showed selective and long-lasting learning and memory impairments in the plus maze, 8-arm radial maze, choice reaction time (CRT) task, and water maze, and that they showed severe brain injury to areas such as parietal cortex, hippocampus, striatum and thalamus. In this study, we examined the effects of hypothermia and hyperthermia on learning and memory deficits following neonatal HI insult. Seven-day-old Wistar rats were subjected to left carotid artery ligation followed by 2 h of hypoxia (8% O2/92% N2) under three different temperature conditions: 27 degrees C (hypothermia), 33 degrees C (normothermia) and 37 degrees C (hyperthermia) in temperature-controlled chambers. Hypothermia significantly reduced attentional deficits in the CRT task and spatial learning deficits in the water maze, and protected against severe brain injury in comparison with the control temperature. On the other hand, hyperthermia aggravated the behavioral deficits and brain injury. These outcomes clearly show that temperature regulation during HI insult plays an important role in the induction of behavioral and histological changes following neonatal HI insult in rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect