A Crossover Study Comparing the Efficacy of Continuous Positive Airway Pressure With Anterior Mandibular Positioning Devices on Patients With Obstructive Sleep Apnea
| Autor: | Glenn T. Clark, Peretz Lavie, Eli Peled, Israel Blumenfeld, Naama Yoffe |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Mandibular advancement splint medicine.medical_treatment Positive pressure Excessive daytime sleepiness Mandible Critical Care and Intensive Care Medicine Positive-Pressure Respiration Sleep Apnea Syndromes medicine Humans Continuous positive airway pressure Cross-Over Studies business.industry Apnea Middle Aged medicine.disease Crossover study nervous system diseases respiratory tract diseases Obstructive sleep apnea Apnea–hypopnea index Anesthesia Orthodontic Appliances Functional Sleep Stages medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Chest. 109:1477-1483 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.109.6.1477 |
| Popis: | Objective This study compared the efficacy of a removable anterior mandibular positioning (AMP) device to continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea (OSA) using a fully balanced crossover design. Design Twenty-three male subjects with confirmed OSA were recruited from the Technion Sleep Laboratory in Haifa, Israel, from February 18, 1991 to December 17, 1992. Twenty-one of the 23 subjects enrolled completed all aspects of the study. Results The mean apnea-hypopnea index (AHI) before treatment was 33.86± 14.30. The mean AHI decreased with CPAP to 59.50%, but decreased only 38.91% with the AMP device. The lowest mean recorded oxygen saturation level for the 21 subjects was 84.30 before treatment, 91.10 after CPAP treatment, and 90.20 after AMP treatment. Sleep data revealed a significant decrease in stage 1 and 2 (p=0.0088) and an increase in rapid eye movement percent (p=0.0066) for both treatments when compared with baseline. Three- to 10-month posttreatment phone interviews showed that 1 subject was not using either device, 1 subject was using CPAP, and 2 subjects were using the AMP device intermittently due to occasional temporomandibular joint pain symptoms. The remaining 17 subjects were all using the AMP device nightly. The symptoms of excessive daytime sleepiness also decreased significantly by both AMP and CPAP. Conclusions The AMP device achieved substantial success in most cases, but was less effective than CPAP, especially for the more severe cases. In general, the AMP device was strongly preferred over the CPAP by the subjects of this study. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|