The correlation of Tim-3 and IFN-γ expressions in mice infected with Toxoplasma gondii during gestation
| Autor: | Jilong Shen, Bin Wu, Shiguang Huang, Fangli Lu, Yan Gan, Bo Huang, Zhao-Rong Lun, Huanqin Zheng, Xiaoyin Fu |
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| Rok vydání: | 2014 |
| Předmět: |
Virus genetics
T cell Real-Time Polymerase Chain Reaction Andrology Interferon-gamma Mice Immune system Pregnancy medicine Animals Hepatitis A Virus Cellular Receptor 2 reproductive and urinary physiology General Veterinary biology Toxoplasma gondii Interleukin General Medicine medicine.disease biology.organism_classification Toxoplasmosis Infectious Diseases Real-time polymerase chain reaction medicine.anatomical_structure Toxoplasmosis Animal Gene Expression Regulation Insect Science Pregnancy Complications Parasitic Immunology Gestation Receptors Virus Parasitology Female Toxoplasma |
| Zdroj: | Parasitology research. 114(1) |
| ISSN: | 1432-1955 |
| Popis: | The immunoinhibitory receptor T cell immunoglobulin domain and mucin domain-1 (Tim-1) and Tim-3 participate in the regulation of Th immune response as well as innate immunity. However, there is no report about the expression of Tim genes in Toxoplasma gondii-infected experimental models during pregnancy. In this study, Kunming outbred pregnant mice were infected with RH strain of T. gondii through vagina at days 10 to 16 of gestation, and the mRNA expressions of Tim-1, Tim-3, interleukin (IL)-4, and interferon (IFN)-γ in the placentas, uteri, and draining lumber aortic lymph nodes (LALNs) at day 18 of gestation were analyzed using quantitative real-time PCR (qRT-PCR). Compared with uninfected pregnant controls, significantly increased levels of IFN-γ and Tim-3 were detected in the placentas (P |
| Databáze: | OpenAIRE |
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