Thiamine Deficiency in Infancy: Long-Term Follow-Up
| Autor: | Sara Kivity, Aviva Mimouni-Bloch, Rachel Strausberg, Hadassa Goldberg-Stern, Rami Fogelman, Eli Heyman, Alex Zvulunov, Ignacio Sztarkier, Aviva Fattal-Valevski, Amichai Brezner, Dov Inbar |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Time Factors Long term follow up Cardiomyopathy Severe epilepsy Epilepsy chemistry.chemical_compound Fatal Outcome Developmental Neuroscience Intellectual Disability medicine Humans Kyphosis Israel Child Kyphoscoliosis Thiamine deficiency Movement Disorders business.industry Persistent Vegetative State Thiamine Deficiency medicine.disease Infant Formula Surgery Scoliosis Neurology chemistry Pediatrics Perinatology and Child Health Female Thiamine Neurology (clinical) business Atrioventricular block Follow-Up Studies |
| Zdroj: | Pediatric Neurology. 51:311-316 |
| ISSN: | 0887-8994 |
| Popis: | Background In 2003, several hundred Israeli infants risked thiamine deficiency after being fed a soy-based formula deficient in thiamine. Approximately 20 patients were seriously affected, and three of them died. We report the clinical presentation of acute encephalopathy in 11 children and the long-term sequelae of eight children who initially survived. Patients In the acute phase, six had bulbar signs, five had ophthalmologic signs and two had phrenic neuropathy. Three of the five patients with cardiac involvement had cardiomyopathy and died in the acute phase. One patient presented with a complete atrioventricular block. Results In the long-term, one patient, who was in a chronic vegetative state, died after 6 years. Seven children exhibited mental retardation and motor abnormalities, six developed severe epilepsy, two early kyphoscoliosis, and one patient remained with a complete atrioventricular block. Conclusions Infants who survive severe infantile thiamine deficiency have serious residual motor and cognitive sequelae as well as epilepsy. |
| Databáze: | OpenAIRE |
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