Polycaprolactone-based in situ implant containing curcumin-PLGA nanoparticles prepared using the multivariate technique
| Autor: | Muthukumar Amirthalingam, Josyula Venkata Rao, Meenashi B Vanthi, Subrahmanyam Mallikarjuna Volety, Narayanan Kasinathan, Neetinkumar D. Reddy |
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| Rok vydání: | 2015 |
| Předmět: |
Curcumin
Materials science Polyesters Sonication Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Nanotechnology 02 engineering and technology 030226 pharmacology & pharmacy Ehrlich ascites carcinoma Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Polylactic Acid-Polyglycolic Acid Copolymer Animals Lactic Acid Drug Implants General Medicine 021001 nanoscience & nanotechnology PLGA chemistry Polycaprolactone Nanoparticles Pharmaceutics Particle size 0210 nano-technology Polyglycolic Acid Biotechnology Homogenization (biology) Biomedical engineering |
| Zdroj: | Artificial Cells, Nanomedicine, and Biotechnology. 44:1520-1528 |
| ISSN: | 2169-141X 2169-1401 |
| DOI: | 10.3109/21691401.2015.1058810 |
| Popis: | Studies on the effect of curcumin/PLGA ratio (CPR), stabilizer (PVA) concentration, homogenization speed, homogenization time, and sonication time on mean particle size (MPS) and percentage drug encapsulation (PDE) were performed using the multivariate technique. MPS and PDE were found to be more dependent on the interaction of sonication time with the other variables. Curcumin was released in a sustained manner from curcumin-PLGA nanoparticles (CPN). CPN improved the survival rate of Ehrlich ascites carcinoma (EAC)-bearing mice and controlled the EAC-induced change in hematological parameters. Histopathology of vital organs showed that the formulation was safe. Polycaprolactone was used in preparing an in situ implant containing CPN. |
| Databáze: | OpenAIRE |
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