Immunocytochemical Demonstration of M1 Muscarinic Acetylcholine Receptors at the Presynaptic and Postsynaptic Membranes of Rat Diaphragm Endplates
| Autor: | Evgeny E. Nikolsky, S. S. Arkhipova, A. I. Malomouzh, František Vyskočil |
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| Rok vydání: | 2011 |
| Předmět: |
Physiology
Diaphragm Neuromuscular Junction Presynaptic Terminals Synaptic Membranes Biology Motor Endplate Synaptic Transmission Postsynaptic potential Muscarinic acetylcholine receptor medicine Animals Receptor Sarcolemma musculoskeletal neural and ocular physiology General Medicine musculoskeletal system Immunohistochemistry Receptors Muscarinic Rats Membrane nervous system Biophysics Neuroscience Free nerve ending Postsynaptic density Acetylcholine medicine.drug |
| Zdroj: | Physiological Research. :185-188 |
| ISSN: | 1802-9973 0862-8408 |
| Popis: | M1-muscarinic acetylcholine (ACh) receptors (M1R) were directly demonstrated immunocytochemically in electronmicroscopic images of rat diaphragm neuromuscular junctions (NMJ). Specific electron-dense granules were located at presynaptic nerve ending membranes and in the sarcolemma in the depths of postsynaptic folds. This first visualization of M1R on both sides of the NMJ is in agreement with previous pharmacological data on the regulatory role of M1R in quantal and non-quantal ACh release. |
| Databáze: | OpenAIRE |
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