The neutrophil–lymphocyte ratio as a marker of systemic endothelial dysfunction in asymptomatic subjects
| Autor: | Oscar Beloqui, Almudena Beltrán, Ana Huerta, Diego Martínez-Urbistondo |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pathology Riesgo cardiovascular Neutrophil–lymphocyte ratio Renal function Cociente albúmina/creatinina urinario 030204 cardiovascular system & hematology Índice neutrófilo/linfocito lcsh:RC870-923 Gastroenterology Asymptomatic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus medicine Endothelial dysfunction Neutrophil to lymphocyte ratio Asymptomatic subjects Creatinine Univariate analysis business.industry Albumin Urinary albumin/creatinine ratio lcsh:Diseases of the genitourinary system. Urology medicine.disease Cardiovascular risk Disfunción endotelial Sujetos asintomáticos 030104 developmental biology chemistry Nephrology medicine.symptom business |
| Zdroj: | Nefrología (English Edition), Vol 36, Iss 4, Pp 397-403 (2016) |
| ISSN: | 2013-2514 |
| DOI: | 10.1016/j.nefroe.2016.11.003 |
| Popis: | Background and objective: The neutrophil-to-lymphocyte ratio has demonstrated to be a prognostic inflammatory marker in cardiovascular disease. The objective of this study is to evaluate the association between neutrophil–lymphocyte ratio and pathologic urinary albumin/creatinine ratio as an early marker of cardiovascular risk and systemic endothelial dysfunction, associated with microvascular disease, in asymptomatic subjects. Materials and methods: A unicenter cross-sectional study was conducted, including 1816 asymptomatic subjects. Patients with previous cardiovascular disease, those who were treated with ACE inhibitors and/or angiotensin II receptor blockers and patients with albumin/creatinine ratio over 300 mg/g were excluded. The outcome of the study was the presence of a pathologic urinary albumin/creatinine ratio. Results: The neutrophil–lymphocyte ratio was significantly associated with altered urinary albumin/creatinine ratio in the univariate analysis and after adjustment for other known endothelial and cardiovascular risk factors (age, hypertension, dyslipidaemia, diabetes or altered glomerular filtration rate). Based on the sensitivity and specificity of different neutrophil–lymphocyte ratio thresholds, 3 risk groups were created for altered urinary albumin/creatinine ratio: low risk in those with neutrophil–lymphocyte ratio 3. These groups were found to have a statistically significant and independent prognostic power for altered urinary albumin/creatinine ratio in asymptomatic patients. Conclusions: The neutrophil–lymphocyte ratio appears to be a cost-efficient, non-invasive and independent potential marker of systemic endothelial dysfunction in asymptomatic subjects. |
| Databáze: | OpenAIRE |
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