ARTERIAL CHEMOINFUSION IN PATIENTS WITH LOCALLY ADVANCED AND METASTATIC PANCREAS CANCER
| Autor: | V. E. Moiseenko, Polikarpov Aa, E.V. Vlasova, Tarazov Pg, E V Rozengaus, A V Pavlovskiy, Kozlov Av, Popov Sa, Granov Da |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
RD1-811 medicine.medical_treatment GemOx regional chemotherapy Gastroenterology diagnostic angiography 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Stage (cooking) Chemotherapy business.industry Cancer General Medicine medicine.disease locally advanced pancreatic cancer Trunk Gemcitabine Oxaliplatin medicine.anatomical_structure 030220 oncology & carcinogenesis Surgery 030211 gastroenterology & hepatology chemoinfusion business Pancreas liver metastases medicine.drug |
| Zdroj: | Вестник хирургии имени И.И. Грекова, Vol 175, Iss 5, Pp 36-40 (2016) |
| ISSN: | 2686-7370 0042-4625 |
| DOI: | 10.24884/0042-4625-2016-175-5-36-40 |
| Popis: | The chemoinfusions (310) were carried out in celiac trunk in 167 patients with non-removed pancreas cancer at the period from 2000 to 2015. Locally advanced timorous process (stage III, n=79) was revealed in 79 patients and liver metastases (stage IV, n=88) were noted in 88 cases. The celiac axis infusion by Gemcitabine (1000 mg/m²) was applied for patients and GEMOX (Gemcitabine+Oxaliplatin 75 mg/m²) has been using since 2012. Symptomatic improvement such as decrease of pain, growth of body weight was noted in majority of patients. An average lifetime, median and one-year survival consisted of 7,6 months, 5,8 months and 10%. The patients (133) were treated by 1-2 cycles and after that by course of total body chemotherapeutics. There weren’t any serious complications. Toxic manifestations of chemotherapy weren’t higher than I-II degree and they were arrested by corrective therapy in 92 patients (55%). The celiac axis infusion is safe in patients with locally advanced and inoperable pancreas cancer. Symptomatic improvement showed the most patients. The objective response to the treatment had 20% patients and performance of repeated cycles led to increase of their survival. |
| Databáze: | OpenAIRE |
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