Porcine Living Liver Transplantation Using a Vascular Prosthesis to Replace the Intrahepatic Vena cava
| Autor: | P Turi, Fausto Catena, Antonino Cavallari, A. Mazziotti, R. Bellusci, Mara Simoncini, F. De Vincentis, Alessandro Faenza, Bruno Nardo |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Vena cava Swine medicine.medical_treatment Biocompatible Materials Vena Cava Inferior Liver transplantation Anastomosis Polypropylenes Blood Vessel Prosthesis Implantation Hepatic Artery Blood vessel prosthesis medicine Animals Vascular prosthesis Portal Vein business.industry Anastomosis Surgical Blood Vessel Prosthesis Liver Transplantation Surgery Transplantation Liver Female Living donor liver transplantation business Liver Circulation |
| Zdroj: | European Surgical Research. 31:364-370 |
| ISSN: | 1421-9921 0014-312X |
| DOI: | 10.1159/000008714 |
| Popis: | Background: This study aimed to determine whether the porcine model could be adapted to accommodate living donor liver transplantation (LLT). Because the pig hepatic anatomy precludes a standard approach, a study was designed to evaluate the results using a segment of vascular prosthesis to replace the intrahepatic portion of the inferior vena cava (IVC) with establishment of hepatic venous drainage into the graft. Methods: A total of 10 LLT were performed using 20 pigs. After left hepatectomy, the intrahepatic IVC was replaced with a modified aorto-iliac prosthesis, anastomosing the proximal (aortic limb) to the infradiaphragmatic IVC, one distal iliac limb to infrahepatic IVC and the other (after shortening) to establish hepatic venous drainage after transplant. Conventional venous bypass was used, and no immunosuppressives were administered. Results: All donors survived the 10-day posthepatectomy observation period. Eight of the 10 transplanted pigs survived at least 2 days (mean 7.6 days; range 3–13 days). No evidence of caval graft thrombosis was observed. Conclusions: Replacement of the recipient intrahepatic IVC by a vascular prosthesis allows to overcome the major technical obstacle which has limited the use of pigs in LLT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|