Mobile phone radiofrequency exposure has no effect on DNA double strand breaks (DSB) in human lymphocytes
| Autor: | Elisa Danese, Martina Montagnana, Dirk Roggenbuck, Ruggero Buonocore, Gian Luca Salvagno, Marco Benati, Giorgio Brocco, Chiara Bonaguri, Giuseppe Lippi, Chiara Bovo |
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| Rok vydání: | 2017 |
| Předmět: |
lymphocytes
0301 basic medicine DNA damage lymphocytes mobile phone DNA Peripheral blood mononuclear cell 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine Significant risk Whole blood Double strand mobile phone Carrier signal business.industry DNA General Medicine 030104 developmental biology chemistry Mobile phone 030220 oncology & carcinogenesis Cancer research Original Article Telecommunications business |
| Zdroj: | Annals of translational medicine. 5(13) |
| ISSN: | 2305-5839 |
| Popis: | Background: The use of mobile phones has been associated with an increased risk of developing certain type of cancer, especially in long term users. Therefore, this study was aimed to investigate the potential genotoxic effect of mobile phone radiofrequency exposure on human peripheral blood mononuclear cells in vitro. Methods: The study population consisted in 14 healthy volunteers. After collection of two whole blood samples, the former was placed in a plastic rack, 1 cm from the chassis of a commercial mobile phone (900 MHz carrier frequency), which was activated by a 30-min call. The second blood sample was instead maintained far from mobile phones or other RF sources. The influence of mobile phone RF on DNA integrity was assessed by analyzing γ-H2AX foci in lymphocytes using immunofluorescence staining kit on AKLIDES. Results: No measure of γ-H2AX foci was significantly influenced by mobile phone RF exposure, nor mobile phone exposure was associated with significant risk of genetic damages in vitro (odds ratio comprised between 0.27 and 1.00). Conclusions: The results of this experimental study demonstrate that exposure of human lymphocytes to a conventional 900 MHz RF emitted by a commercial mobile phone for 30 min does not significantly impact DNA integrity. |
| Databáze: | OpenAIRE |
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