Modulating Selectivity in Nanogap Sensors
| Autor: | Klaus Mathwig, Serge G. Lemay, Hamid Reza Zafarani, Liza Rassaei, Ernst J. R. Sudhölter |
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| Přispěvatelé: | Pharmaceutical Analysis, Medicinal Chemistry and Bioanalysis (MCB), Bio electronics |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Bioengineering Nanotechnology Nanofluidics nanogap sensor 02 engineering and technology URIC-ACID Electrochemistry nanofluidics 01 natural sciences Redox INTERDIGITATED ARRAY ELECTRODE DOPAMINE INTERFERENCE-FREE Instrumentation nanoelectrochemistry IMMUNOSENSOR Fluid Flow and Transfer Processes NANOFLUIDIC CHANNELS Nanoelectrochemistry Process Chemistry and Technology 010401 analytical chemistry selectivity ELECTROCHEMICAL DETECTION redox cycling 021001 nanoscience & nanotechnology Ascorbic acid 0104 chemical sciences VOLTAMMETRIC DETERMINATION Standard electrode potential ASCORBIC-ACID Electrode BIOSENSORS 0210 nano-technology Biosensor |
| Zdroj: | ACS Sensors, 1(12), 1439-1444. AMER CHEMICAL SOC INC ACS sensors, 1(12), 1439-1444. American Chemical Society |
| ISSN: | 2379-3694 |
| Popis: | Interference or crosstalk of coexisting redox species results in overlapping of electrochemical signals, and it is a major hurdle in sensor development. In nanogap sensors, redox cycling between two independently biased working electrodes results in an amplified electrochemical signal and an enhanced sensitivity. Here, we report new strategies for selective sensing of three different redox species in a nanogap sensor of a 2 fL volume. Our approach relies on modulating the electrode potentials to define specific potential windows between the two working electrodes; consequently, specific detection of each redox species is achieved. Finite element modeling is employed to simulate the electrochemical processes in the nanogap sensor, and the results are in good agreement with those of experiments. |
| Databáze: | OpenAIRE |
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