Quantitative Determinants of the Outcome of Asymptomatic Mitral Regurgitation
| Autor: | Maryann Capps, David Messika-Zeitoun, Delphine Detaint, Maurice Enriquez-Sarano, Vuyisile T. Nkomo, Christopher G. Scott, A. Jamil Tajik, Hartzell V. Schaff, Jean François Avierinos |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Effective Regurgitant Orifice Area Severity of Illness Index Asymptomatic Predictive Value of Tests Internal medicine Mitral valve Atrial Fibrillation medicine Humans Ventricular Function Prospective Studies Survival rate Aged Proportional Hazards Models Heart Failure Analysis of Variance Mitral regurgitation Ejection fraction business.industry Hemodynamics Mitral Valve Insufficiency Atrial fibrillation General Medicine Middle Aged Prognosis medicine.disease Echocardiography Doppler Confidence interval Survival Rate Treatment Outcome medicine.anatomical_structure Cardiology Mitral Valve Female medicine.symptom business |
| Zdroj: | New England Journal of Medicine. 352:875-883 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | background The clinical outcome of asymptomatic mitral regurgitation is poorly defined, and the treatment is uncertain. We studied the effect on the outcome of quantifying mitral regurgitation according to recent guidelines. methods We prospectively enrolled 456 patients (mean [±SD] age, 63±14 years; 63 percent men; ejection fraction, 70±8 percent) with asymptomatic organic mitral regurgitation, quantified according to current recommendations (regurgitant volume, 66±40 ml per beat; effective regurgitant orifice, 40±27 mm 2 ). results The estimated five-year rates (±SE) of death from any cause, death from cardiac causes, and cardiac events (death from cardiac causes, heart failure, or new atrial fibrillation) with medical management were 22±3 percent, 14±3 percent, and 33±3 percent, respectively. Independent determinants of survival were increasing age, the presence of diabetes, and increasing effective regurgitant orifice (adjusted risk ratio per 10-mm 2 increment, 1.18; 95 percent confidence interval, 1.06 to 1.30; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|