| Autor: |
Hongming Li, Yumei Qiu, Mengdie Xie, Changsheng Ouyang, Xiaoyun Ding, Hao Zhang, Wei Dong, Yinhua Xiong, Xilan Tang |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
The Korean journal of physiologypharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. 27(1) |
| ISSN: |
1226-4512 |
| Popis: |
This study aimed to observe the protective effect of momordicine I, a triterpenoid compound extracted from momordica charantia L., on isoproterenol (ISO)-induced hypertrophy in rat H9c2 cardiomyocytes and investigate its potential mechanism. Treatment with 10 μM ISO induced cardiomyocyte hypertrophy as evidenced by increased cell surface area and protein content as well as pronounced upregulation of fetal genes including atrial natriuretic peptide, β-myosin heavy chain, and α-skeletal actin; however, those responses were markedly attenuated by treatment with 12.5 μg/ml momordicine I. Transcriptome experiment results showed that there were 381 and 447 differentially expressed genes expressed in comparisons of model/control and momordicine I intervention/model, respectively. GO enrichment analysis suggested that the anti-cardiomyocyte hypertrophic effect of momordicine I may be mainly associated with the regulation of metabolic processes. Based on our transcriptome experiment results as well as literature reports, we selected glycerophospholipid metabolizing enzymes group VI phospholipase A |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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