Clostridium perfringens-mediated necrotic enteritis is not influenced by the pre-existing microbiota but is promoted by large changes in the post-challenge microbiota
| Autor: | Priscilla A. Johanesen, Anthony L. Keyburn, Dena Lyras, Jake A. Lacey, Dragana Stanley, Honglei Chen, Robert J. Moore, Mark E Ford |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Clostridium perfringens 030106 microbiology Disease Biology Gut flora medicine.disease_cause digestive system Microbiology Enteritis Clostridia 03 medical and health sciences Necrosis fluids and secretions RNA Ribosomal 16S medicine Animals Feces Poultry Diseases Gastrointestinal tract General Veterinary General Medicine biology.organism_classification medicine.disease Gastrointestinal Microbiome stomatognathic diseases 030104 developmental biology Clostridium Infections Dysbiosis Microbial Interactions Chickens |
| Zdroj: | Veterinary microbiology. 227 |
| ISSN: | 1873-2542 |
| Popis: | Problem addressed: Clostridium perfringens is the etiological agent of necrotic enteritis in chickens. As necrotic enteritis is a gastrointestinal disease, the interactions of pathogenic C. perfringens strains with the complex microbiota of the gastrointestinal tract may influence disease development and severity of disease. Objective: In this study the interactions of a pathogenic strain of C. perfringens, WER-NE36, with the microbiota of broilers was investigated to determine whether the pre-existing microbiota could influence disease outcomes in the necrotic enteritis challenge model. Methods and approach: Faecal microbiota compositions were measured before and after C. perfringens challenge and caecal microbiota was also characterised at necropsy. The microbiota profiles from individual birds were related back to the degree of necrotic enteritis that each bird developed. Results: Under the experimental conditions used the pre-existing microbiota did not have an effect on disease outcomes. However, C. perfringens challenge was shown to have a significant effect on the microbiota of broilers, regardless of disease status, by displacement of commensal clostridia. Conclusions: The microbiota signature after challenge resembled that of lower productivity birds, supporting the finding that physically obvious disease (necrotic lesions), as well as dysbiosis, are associated with shifts in gut microbiota and affect broiler performance, increasing costs to the poultry industry. |
| Databáze: | OpenAIRE |
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