Comparison of extraarticular leakage values of radiopharmaceuticals used for radionuclide synovectomy
| Autor: | Bülent Atilla, Gonca Kara Gedik, Bedri Seven, Murat Pekmezci, Erhan Varoglu, Mustafa Yildirim, Omer Ugur |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Synovectomy Severity of Illness Index law.invention law Synovitis medicine Humans Tissue Distribution Radiology Nuclear Medicine and imaging Child Radionuclide Imaging Lymph node Leakage (electronics) Gamma camera Radioisotopes Radionuclide business.industry General Medicine Middle Aged medicine.disease medicine.anatomical_structure Pigmented villonodular synovitis Rheumatoid arthritis Female Radiology Radiopharmaceuticals business Nuclear medicine Extravasation of Diagnostic and Therapeutic Materials |
| Zdroj: | Annals of Nuclear Medicine. 20:183-188 |
| ISSN: | 1864-6433 0914-7187 |
| DOI: | 10.1007/bf03027428 |
| Popis: | Radionuclide synovectomy is a reliable therapy in patients with chronic synovitis. However, radiation doses delivered to non-target organ systems due to leakage of radioactive material from the articular cavity are an important disadvantage of this procedure. In this study we compared extraarticular leakage values of the 3 commonly used radiopharmaceuticals;90Y-citrate,90Y-silicate and186Re-sulfide colloid. Thirty-five patients with persistent synovitis were enrolled in the study. Twenty-two hemophilic, 8 rheumatoid arthritis and 5 patients with pigmented villonodular synovitis were studied.90Y labeled silicate and citrate were used for knee joints and186Re-sulfide for intermediate sized joints. Radiocolloid leakage values were evaluated using a gamma camera with 20% window centered over the bremsstrahlung photopeak of90Y and a respective window over the 137 keV photopeak of186Re. Regions of interest were drawn over the injection site, the regional lymph nodes and the background areas. Leakage of radiocolloid was calculated by dividing the counts/pixel in the regional lymph node area to the counts/pixel in the injection site. No visible leakage was observed. The median leakage values calculated for90Y-citrate,90Y-silicate and186Re-sulfide were found as 1.9%, 2.4% and 2.7%, respectively. The difference between the variability of leakage values was not statistically significant (p > 0.05).Conclusion: There was no significant difference in terms of extraarticular leakage between90Y-citrate,90Y-silicate and186Re-sulfide radiocolloids. |
| Databáze: | OpenAIRE |
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