[Significance of serum oxidative stress related markers and genotype of GST gene in the pathogeneses of primary biliary cirrhosis]
| Autor: | Kenichi Sato, Osamu Komuro, Hiroki Takahashi, Shigeo Tamaki, Gotaro Toda, Mikio Zeniya |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Genotype Immunology medicine.disease_cause Peripheral blood mononuclear cell Gastroenterology Pathogenesis Primary biliary cirrhosis Thioredoxins Internal medicine medicine Immunology and Allergy Humans Clinical significance Glutathione Transferase Autoimmune disease business.industry Liver Cirrhosis Biliary Superoxide Dismutase Deoxyguanosine General Medicine Middle Aged medicine.disease Titer Oxidative Stress 8-Hydroxy-2'-Deoxyguanosine Female business Oxidative stress |
| Zdroj: | Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology. 27(5) |
| ISSN: | 0911-4300 |
| Popis: | The studies using an immunohistological technique revealed that overexpression of oxidative stress-related substance such as HNE was observed in the liver of primary biliary cirrhosis patients. These data suggested that oxidative stress participated in the pathogenesis of primary biliary cirrhosis. Therefore we analyzed serum oxdative stress marker (8-OHdG) and anti oxidative substances (Mn-SOD and TRX) to evaluate their clinical significance. In addition we analyzed the genotype of anti oxidative substance GST that has been reported to relate susceptibility of autoimmune disease. Serum levels of 8-OHdG, Mn-SOD and TRX in PBC patients were significantly higher than those of healthy subjects (P |
| Databáze: | OpenAIRE |
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