ASSOCIATION OF HAPTOGLOBIN LEVELS WITH AGE, PARASITE DENSITY, AND HAPTOGLOBIN GENOTYPE IN A MALARIA-ENDEMIC AREA OF GABON

Autor: Phillipe Deloron, Freya J. I. Fowkes, Heather Imrie, Adrian J. F. Luty, Pascal Michon, Florence Migot-Nabias, Anita Justice, Karen P. Day
Rok vydání: 2006
Předmět:
Male
Aging
ANALYSE DE COHORTES
Physiology
Plasmodium malariae
Parasitemia
0302 clinical medicine
Genotype
TECHNIQUE PCR
Child
ANALYSE STATISTIQUE
0303 health sciences
education.field_of_study
biology
Haptoglobin
AGE PHYSIOLOGIQUE
DENSITE DE POPULATION
GENOTYPE
3. Good health
Pathogenesis and modulation of inflammation [N4i 1]
ENFANT
Infectious Diseases
Child
Preschool
Female
Plasmodium falciparum
030231 tropical medicine
Population
Sickle Cell Trait
03 medical and health sciences
TEST ELISA
Virology
ABO blood group system
PROTEINE
parasitic diseases
medicine
Animals
Humans
Gabon
PARASITE
education
HAPTOGLOBINE
030304 developmental biology
SAISON HUMIDE
Sickle cell trait
Haptoglobins
Infant
PALUDISME
biology.organism_classification
medicine.disease
Malaria
Cross-Sectional Studies
Immunology
biology.protein
Parasitology
Microbial pathogenesis and host defense [UMCN 4.1]
Immunity
infection and tissue repair [NCMLS 1]
Zdroj: Scopus-Elsevier
American Journal of Tropical Medicine and Hygiene, 74, 26-30
Europe PubMed Central
American Journal of Tropical Medicine and Hygiene, 74, 1, pp. 26-30
ISSN: 1476-1645
0002-9637
DOI: 10.4269/ajtmh.2006.74.26
Popis: Item does not contain fulltext Haptoglobin (Hp) levels were investigated in relation to host genotype in a malaria-endemic area in Gabon. A cross-sectional study of 1-12-year-old children was conducted in the rainy season, a period of high malaria transmission, to examine this relationship. Variables that influenced Hp levels were Hp genotype, location, and age interacting with parasite density. At low parasite densities, there was a negative correlation between Hp levels and age. At higher densities, there was a positive correlation with age. This suggests that in the presence of greater parasite-induced hemolysis, older children are capable of increased production of Hp. Sickle cell trait and ABO blood group was not associated with Hp levels in this population.
Databáze: OpenAIRE
Externí odkaz: