Antimicrobial resistance of urinary tract pathogens in children in Crete, Greece

Autor:	Amalia Tsilimigaki, Maria Anatoliotaki, Sofia Stefanaki, Athina Schinaki, Maria Mavrokosta, Emmanouil Galanakis
Rok vydání:	2007
Předmět:	Male Microbiology (medical) medicine.medical_specialty Adolescent Drug resistance Biology urologic and male genital diseases Microbiology Drug Resistance Multiple Bacterial Internal medicine Ampicillin Escherichia coli medicine Humans Prospective Studies Child Escherichia coli Infections Antibacterial agent First episode Greece General Immunology and Microbiology Sulfamethoxazole Enterobacteriaceae Infections Infant General Medicine bacterial infections and mycoses female genital diseases and pregnancy complications Community-Acquired Infections Infectious Diseases Nitrofurantoin Child Preschool Urinary Tract Infections Female Cefuroxime Cefaclor medicine.drug
Zdroj:	Scandinavian Journal of Infectious Diseases. 39:671-675
ISSN:	1651-1980 0036-5548
DOI:	10.1080/00365540701199899
Popis:	The aim of the present study was to identify the organisms responsible for community acquired febrile UTI in children and to investigate their susceptibility to commonly used antibiotics. A 5-y prospective analysis was performed in children hospitalized for a first episode of UTI, in Crete, Greece. A total of 262 children, 40.1% males and 59.9% females, aged 0.08 to 13 y, were enrolled in the study. Escherichia coli (E. coli) was the leading uropathogen. Antimicrobial resistance of E. coli isolates was most commonly to ampicillin (56.4%) followed by trimethoprim-sulfamethoxazole (TMP-SMX) (27.3%), cefaclor (22.5%), amoxicillin-clavulanate (15.5%), gentamicin (4.9%), cefuroxime (3.1%), nitrofurantoin (2.6%), and ceftriaxone (1.6%). Interestingly, a significant decrease in E. coli resistance to TMP-SMX was observed during the study period. Resistance to ampicillin, TMP-SMX and cefaclor was noted for 61%, 28% and 27% of the total uropathogens, respectively, making these agents inappropriate for empirical treatment of febrile UTI in our region. A larger number of pathogens may be empirically treated with amoxicillin-clavulanate. More than 90% of the uropathogens are susceptible to cefuroxime, ceftriaxone, gentamicin, and nitrofurantoin. In conclusion, several of the first-line agents for empirical treatment of childhood UTI seem to have become ineffective in the area of this study.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ffb5e0be51d9f6c7a5754b0144102d https://doi.org/10.1080/00365540701199899 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.