Major central nervous system complications after allogeneic stem cell transplantation: A large retrospective study on 888 consecutive adult patients
Autor: | Tatiana Theresa Urbanowicz, Laura Berneking, Christine Wolschke, Nicolaus Kröger, Ulrich Grzyska, Anna Both, Jens Fiehler, Chi Un Choe, Francis Ayuk, Maximilian Christopeit, Sabine Rösner, Daniele Mannina, Nicole Fischer, Wiebke Timm |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male medicine.medical_specialty Allogeneic transplantation Central nervous system 03 medical and health sciences 0302 clinical medicine Central Nervous System Diseases Recurrence Risk Factors Internal medicine medicine Humans Transplantation Homologous Cumulative incidence Mortality Retrospective Studies business.industry Incidence (epidemiology) Incidence Neurotoxicity Hematopoietic Stem Cell Transplantation Retrospective cohort study Hematology General Medicine medicine.disease Prognosis Transplantation medicine.anatomical_structure 030220 oncology & carcinogenesis Female Disease Susceptibility Morbidity business Complication 030215 immunology |
Zdroj: | European journal of haematologyREFERENCES. 105(6) |
ISSN: | 1600-0609 |
Popis: | OBJECTIVES Major complications affecting the central nervous system (CNS) present a challenge after allogeneic stem cell transplantation (allo-SCT). METHODS Incidence, risk factors, and outcome were retrospectively analyzed in 888 patients in a monocentric study. RESULTS Cumulative incidence (CI) of major CNS complications at 1 year was 14.8% (95%CI 12.3%-17.2%). Median follow-up is 11 months. CNS complications were documented in 132 patients: in 36 cases, classified metabolic; 26, drug-related neurotoxicity (14 attributed to cyclosporine A, 4 to antilymphocyte globulin); 11, cerebrovascular (ischemic n = 8, bleeding n = 3); 9, infections; 9, psychiatric; and 9, malignant. The cause of CNS symptoms remained unclear for 37 patients (28%). Multivariate analysis demonstrated an association of CNS complication with patient age (P |
Databáze: | OpenAIRE |
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