Major central nervous system complications after allogeneic stem cell transplantation: A large retrospective study on 888 consecutive adult patients

Autor: Tatiana Theresa Urbanowicz, Laura Berneking, Christine Wolschke, Nicolaus Kröger, Ulrich Grzyska, Anna Both, Jens Fiehler, Chi Un Choe, Francis Ayuk, Maximilian Christopeit, Sabine Rösner, Daniele Mannina, Nicole Fischer, Wiebke Timm
Rok vydání: 2020
Předmět:
Zdroj: European journal of haematologyREFERENCES. 105(6)
ISSN: 1600-0609
Popis: OBJECTIVES Major complications affecting the central nervous system (CNS) present a challenge after allogeneic stem cell transplantation (allo-SCT). METHODS Incidence, risk factors, and outcome were retrospectively analyzed in 888 patients in a monocentric study. RESULTS Cumulative incidence (CI) of major CNS complications at 1 year was 14.8% (95%CI 12.3%-17.2%). Median follow-up is 11 months. CNS complications were documented in 132 patients: in 36 cases, classified metabolic; 26, drug-related neurotoxicity (14 attributed to cyclosporine A, 4 to antilymphocyte globulin); 11, cerebrovascular (ischemic n = 8, bleeding n = 3); 9, infections; 9, psychiatric; and 9, malignant. The cause of CNS symptoms remained unclear for 37 patients (28%). Multivariate analysis demonstrated an association of CNS complication with patient age (P
Databáze: OpenAIRE
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