Mechanical behavior of actin and spectrin subjected to high strain rate: A molecular dynamics simulation study
| Autor: | Ashfaq Adnan, Sheikh Fahad Ferdous, Ishak Khan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
High strain rate
Materials science Biophysics macromolecular substances Biochemistry Axon 03 medical and health sciences Molecular dynamics 0302 clinical medicine Structural Biology Axonal cytoskeleton Genetics medicine Spectrin Mechanical behavior Cytoskeleton Actin 030304 developmental biology ComputingMethodologies_COMPUTERGRAPHICS 0303 health sciences Stiffness Strain rate Computer Science Applications 030220 oncology & carcinogenesis medicine.symptom TP248.13-248.65 Biotechnology Research Article |
| Zdroj: | Computational and Structural Biotechnology Journal Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1738-1749 (2021) |
| ISSN: | 2001-0370 |
| Popis: | Graphical abstract Highlights • Actin: Strain rate and length dependent failure or stretching. • Spectrin: Strain rate dependent unfolding of inter-repeat regions. • Actin-Spectrin Network: strain rate dependent vulnerable regions are actin-spectrin interface or spectrin interrepeats. Recent nanoscopy and super-resolution microscopy studies have substantiated the structural contribution of periodic actin-spectrin lattice to the axonal cytoskeleton of neuron. However, sufficient mechanical insight is not present for spectrin and actin-spectrin network, especially in high strain rate scenario. To quantify the mechanical behavior of actin-spectrin cytoskeleton in such conditions, this study determines individual stretching characteristics of actin and spectrin at high strain rate by molecular dynamics (MD) simulation. The actin-spectrin separation criteria are also determined. It is found that both actin and spectrin have high stiffness when susceptible to high strain rate and show strong dependence on applied strain rate. The stretching stiffness of actin and forced unfolding mechanism of spectrin are in harmony with the current literature. Actin-spectrin model provides novel insight into their interaction and separation stretch. It is shown that the region vulnerable to failure is the actin-spectrin interface at lower strain rate, while it is the inter-repeat region of spectrin at higher strain rate. |
| Databáze: | OpenAIRE |
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