Synthesis of ganglioside epitopes for oligosaccharide specific immunoadsorption therapy of Guillian-Barré syndrome
| Autor: | Hugh J. Willison, Chang-Chun Ling, David R. Bundle, Ping Zhang, Kate Townson, Søren M. Andersen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
Ganglioside Molecular Sequence Data Organic Chemistry Antibodies Monoclonal Oligosaccharides Glycoside G(M2) Ganglioside Oligosaccharide Guillain-Barre Syndrome Ligands Biochemistry Epitope Antigen-Antibody Reactions Carbohydrate Sequence chemistry Gangliosides Humans Physical and Theoretical Chemistry Immunosorbents Immunoadsorption Immunosorbent Techniques Function (biology) Neuromuscular Nondepolarizing Agents |
| Zdroj: | Org. Biomol. Chem.. 2:1199-1212 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/b400029c |
| Popis: | Guillain-Barré syndrome is a postinfectious, autoimmune neuropathy resulting in neuromuscular paralysis. Auto-antibodies, often induced by bacterial infection, bind to human gangliosides possessing monosialoside and diasialoside epitopes and impair the function of nerve junctions, where these ganglioside structures are highly enriched. Truncated gangliosides representive of GD3, GQ1b and GM2 epitopes have been synthesized as methyl glycosides and as a glycosides of an eleven carbon tether. The synthetic oligosaccharide ligands are structural mimics of these highly complex ganglioside epitopes and via their ability to neutralize or remove auto-antibodies have the potential for therapy, either as soluble blocking ligands administered systemically, or as immuno-affinity ligands for use as extracorporeal immunoadsorbents. |
| Databáze: | OpenAIRE |
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