Myrcene mimics the peripheral analgesic activity of lemongrass tea
| Autor: | Glória Emília Petto de Souza, B B Lorenzetti, S J Sarti, David dos Santos Filho, Sérgio H. Ferreira |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Acyclic Monoterpenes
Analgesic Prostaglandin Pharmacology Mass Spectrometry law.invention Terpene Beverages chemistry.chemical_compound Mice law Cymbopogon citratus Drug Discovery medicine Oils Volatile Reaction Time Animals Prostaglandin E2 Essential oil Analgesics Plants Medicinal biology Dose-Response Relationship Drug business.industry Terpenes Nociceptors Rats Inbred Strains Drug Tolerance biology.organism_classification Rats chemistry Anesthesia Myrcene Hyperalgesia Monoterpenes Chromatography Thin Layer medicine.symptom business medicine.drug |
| Zdroj: | Journal of ethnopharmacology. 34(1) |
| ISSN: | 0378-8741 |
| Popis: | Oral administration of an infusion of lemongrass (Cymbopogon citratus) fresh leaves to rats produced a dose-dependent analgesia for the hyperalgesia induced by subplantar injections of either carrageenin or prostaglandin E2, but did not affect that induced by dibutyryl cyclic AMP. These results indicate a peripheral site of action which was confirmed with the essential oil obtained by steam distillation of the leaves. Silica gel column fractionation of the essential oil allowed the identification of myrcene as the major analgesic component in the oil. Identification of the components was made by thin-layer chromatography and checked by mass spectrometry. The peripheral analgesic effect of myrcene was confirmed by testing a standard commercial preparation on the hyperalgesia induced by prostaglandin in the rat paw test and upon the contortions induced by intraperitoneal injections of iloprost in mice. In contrast to the central analgesic effect of morphine, myrcene did not cause tolerance on repeated injection in rats. This analgesic activity supports the use of lemongrass tea as a "sedative" in folk medicine. Terpenes such as myrcene may constitute a lead for the development of new peripheral analgesics with a profile of action different from that of the aspirin-like drugs. |
| Databáze: | OpenAIRE |
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