Is There a Relationship Between Fatigue Perception and the Serum Levels of Thyrotropin and Free Thyroxine in Euthyroid Subjects?
| Autor: | Romana T. Netea-Maier, Martin den Heijer, Annenienke C van de Ven, Fred C.G.J. Sweep, Ad R. M. M. Hermus, Lambertus A. Kiemeney, H. Alec Ross, Femmie de Vegt |
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| Přispěvatelé: | Internal medicine, ICaR - Circulation and metabolism |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty endocrine system endocrine system diseases Endocrinology Diabetes and Metabolism Thyrotropin Aetiology screening and detection [ONCOL 5] Iodide Peroxidase Endocrinology Thyroid peroxidase Surveys and Questionnaires Internal medicine Serum TSH level Humans Medicine Hormonal regulation Molecular epidemiology [IGMD 6] Euthyroid Hormonal regulation Translational research [IGMD 6] Fatigue Normal range Health aging / healthy living Cardiovascular diseases [IGMD 5] Aged Autoantibodies Molecular epidemiology Aetiology screening and detection [NCEBP 1] biology business.industry Hormonal regulation [IGMD 6] Free thyroxine Middle Aged Thyroid Diseases Confidence interval Thyroxine Relative risk biology.protein Hormonal regulation Aetiology screening and detection [IGMD 6] Female Perception business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Thyroid, 22(12), 1236-1243. Mary Ann Liebert Inc. van de Ven, A C, Netea-Maier, R T, de Vegt, F, Ross, H A, Sweep, F C G J, Kiemeney, L A, Hermus, A R & den Heijer, M 2012, ' Is There a Relationship Between Fatigue Perception and the Serum Levels of Thyrotropin and Free Thyroxine in Euthyroid Subjects? ', Thyroid, vol. 22, no. 12, pp. 1236-1243 . https://doi.org/10.1089/thy.2011.0200 Thyroid, 22, 1236-43 Thyroid, 22, 12, pp. 1236-43 |
| ISSN: | 1050-7256 |
| DOI: | 10.1089/thy.2011.0200 |
| Popis: | Item does not contain fulltext Background: Thyrotoxicosis and hypothyroidism are associated with fatigue. Here we studied euthyroid subjects to determine if there was a relationship between serum thyrotropin (TSH), free thyroxine (FT(4)) and thyroperoxidase antibodies and fatigue. Methods: A total of 5897 participants of the Nijmegen Biomedical Study received a questionnaire and serum TSH (normal range 0.4-4.0 mIU/L) and FT(4) (normal range 8-22 pmol/L) were measured. Fatigue was evaluated by the RAND-36 and the shortened fatigue questionnaire (SFQ). Results: Euthyroid subjects with a serum TSH level of 0.4-1.0 mIU/L had a lower RAND-36 vitality score (65.2 vs. 66.8; regression coefficient (RC) -1.6 [95% confidence interval (CI) -2.6 to -0.5]; p=0.005) and a higher SFQ score (11.7 vs. 11.0; RC 0.6 [CI 0.2-1.0]; p=0.004) than those with a TSH of 1.0-2.0 mIU/L. Those with a serum FT(4) of 18.5-22 pmol/L reported fatigue more often (52.5% vs. 33.3%; relative risk (RR) 1.4 [CI 1.0-1.9]; p=0.03), had a lower RAND-36 vitality score (61.7 vs. 66.6; RC -4.4 [CI -8.1 to -0.6]; p=0.02) and a higher SFQ score (13.2 vs. 11.0; RC 1.9 [CI 0.4-3.3]; p=0.01) than subjects with a FT(4) level of 11.5-15 pmol/L. In comparison to euthyroid subjects without known thyroid disease, euthyroid subjects with previously known thyroid disease reported fatigue more often (52.3% vs. 34.0%; RR 1.3 [CI 1.0-1.5]; p=0.025), had a lower RAND-36 vitality score (61.4 vs. 66.3; RC -2.9 [CI -5.3 to -0.6]; p=0.015) and a higher SFQ score (13.7 vs. 11.1; RC 1.4 [CI 0.5-2.3]; p=0.002). Conclusion: In euthyroid individuals without a history of thyroid disease, there is a modest relationship between thyroid function and fatigue with subjects having an apparently higher production of T(4) experiencing more fatigue. Subjects with a history of thyroid disease, but with normal TSH and FT(4) concentrations, experience more fatigue than the general population. The reasons for this are unclear, but subtle abnormalities in the dynamics of thyroid hormone secretion should be considered. |
| Databáze: | OpenAIRE |
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