Autofluorescence Imaging of Choroidal Neovascularization Due to Age-Related Macular Degeneration
| Autor: | Kulwant S. Sehmi, Tunde Peto, Samantha S. Dandekar, Sharon Jenkins, Fred W. Fitzke, Hendrik P. N. Scholl, Alan C. Bird, Andrew R. Webster |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Diagnostic Imaging
Male medicine.medical_specialty genetic structures Fluorescence Lipofuscin Macular Degeneration chemistry.chemical_compound Ophthalmology medicine Humans Fluorescein Angiography Fluorescein Pigment Epithelium of Eye Aged Aged 80 and over Retinal pigment epithelium medicine.diagnostic_test business.industry Middle Aged Macular degeneration Fluorescein angiography medicine.disease Choroidal Neovascularization eye diseases Autofluorescence Choroidal neovascularization medicine.anatomical_structure chemistry Optometry Maculopathy Female sense organs medicine.symptom business |
| Zdroj: | Archives of Ophthalmology. 123:1507 |
| ISSN: | 0003-9950 |
| DOI: | 10.1001/archopht.123.11.1507 |
| Popis: | Objective To describe the autofluorescence (AF) characteristics of choroidal neovascularization (CNV) in patients with age-related macular degeneration. Methods Autofluorescence images of 65 consecutive eyes with CNV at various stages of evolution were analyzed. Twenty images were of recent-onset CNV (group 1), 8 were of eyes 1 to 6 months after CNV diagnosis (group 2), and 37 were late-stage CNV (group 3). Autofluorescence images from groups 1 and 2 were compared with fundus fluorescein angiographic images. Results Group 1 showed areas of hyperfluorescence on fundus fluorescein angiography corresponding to areas of normal AF in 16 of 20 cases, with adjacent areas of increased AF in 13 cases. The main areas of abnormal AF were larger than the main areas of abnormal fluorescence on fundus fluorescein angiography in 18 of the 20 cases. Groups 2 and 3 showed areas of decreased AF corresponding to areas of previous leakage on fundus fluorescein angiography (in group 2) or atrophy. Conclusions Preserved AF in group 1 indicates viable retinal pigment epithelium initially, which has implications for visual prognosis. Decreased AF in groups 2 and 3 indicates loss of retinal pigment epithelium and photoreceptors. Autofluorescence imaging may increase our understanding of CNV in age-related macular degeneration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|