Influence of normal aging on oral-pharyngeal and upper esophageal sphincter function during swallowing
| Autor: | D. W. Shaw, I. J. Cook, M. Gabb, R. H. Holloway, M. E. Simula, V. Panagopoulos, J. Dent |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Senescence Aging Adolescent Physiology Muscle Relaxation Normal aging Pharyngeal muscles Bolus (medicine) Swallowing Physiology (medical) Pressure medicine Humans Aged Aged 80 and over Hepatology business.industry digestive oral and skin physiology Gastroenterology Middle Aged Deglutition medicine.anatomical_structure Muscle relaxation Anesthesia Pharyngeal Muscles Sphincter Female Esophagogastric Junction Oral pharyngeal business |
| Zdroj: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 268:G389-G396 |
| ISSN: | 1522-1547 0193-1857 |
| Popis: | The influence of aging on oral-pharyngeal swallowing was assessed by simultaneous manometry and videoradiography in 14 nondysphagic elderly individuals (mean age 76 yr) and 11 healthy, young controls (mean age 21 yr). Sphincter opening was diminished significantly in the elderly (P = 0.0001), but trans-sphincteric bolus flow rates were preserved. The increased impedance to trans-sphincteric bolus flow from reduced sphincter opening in the aged was reflected in a significant increase in hypopharyngeal intrabolus pressure (P = 0.003). Oral transit time was significantly prolonged in the aged (P = 0.01). The timing of upper esophageal sphincter (UES) manometric relaxation and of opening was significantly delayed in the aged (P = 0.0001), and this delay was comparable in magnitude to the prolongation in oral transit. Coordination of UES relaxation and opening with midpharyngeal contraction was not significantly affected by age. Deglutitive hyolaryngeal motion was not affected by age but was delayed by a duration equivalent to the prolongation in oral transit. We conclude that normal aging prolongs the oral-pharyngeal swallow that impairs UES opening but does not influence pharyngo-sphincteric coordination. |
| Databáze: | OpenAIRE |
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