Prevalence, clinical characteristics, and outcomes of pediatric COVID-19: A systematic review and meta-analysis
| Autor: | Bishnu Bahadur Bajgain, Sujan Badal, Rama Thapa, Kalpana Thapa Bajgain, Sujeena Badal, Maria J. Santana |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 030106 microbiology Population MEDLINE Scopus Disease Outcomes Severity Article 03 medical and health sciences 0302 clinical medicine Virology Health care Pandemic medicine Prevalence Humans CNKI China knowledge resource integrated 030212 general & internal medicine education Child Pandemics Letter to the Editor Pediatric education.field_of_study Clinical characteristics business.industry SARS-CoV-2 RT-PCR reverse transcriptase PCR Neonates COVID-19 Publication bias Meta-analysis Infectious Diseases Family medicine Systematic review business |
| Zdroj: | Journal of Clinical Virology |
| ISSN: | 1386-6532 |
| DOI: | 10.1016/j.jcv.2020.104715 |
| Popis: | Highlights • COVID-19 pediatric data from major world-wide epicenters is severely lacking as compared to the adult population. • Pediatric cases of COVID-19 tend to have a mild course and an overall favorable prognosis. • Clinical, laboratory, and radiological features are largely inconsistent and solely not predictive of the disease diagnosis. • This study may provide important insights into the characterization and management of COVID-19 in the pediatric population. Introduction The novel coronavirus pandemic is an ongoing challenge faced by the public and health care systems around the globe. Majority of information and evidence gathered so far regarding COVID-19 has been derived from data and studies in adult populations. Crucial information regarding the characterization, clinical symptomatology, sequelae, and overall outcomes in the pediatric population is lacking. As such, we aimed to conduct a comprehensive meta-analysis and systematic review to collect and analyze current evidence about COVID-19 in the pediatric population. Method A systematic search and review of scientific literatures was conducted following the PRISMA guidelines using PubMed, Embase, Scopus, Medline, and Google Scholar databases. All relevant studies until June 16, 2020 were included. Studies were reviewed for methodological quality, and random-effects model was used to conduct the primary meta-analysis. I2 value and Egger’s test was used to estimate heterogeneity and publication bias respectively. Results We reviewed 20 eligible studies that included 1810 pediatric patient population ( |
| Databáze: | OpenAIRE |
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