Essential Hypertension Is Associated With Changes in Gut Microbial Metabolic Pathways: A Multisite Analysis of Ambulatory Blood Pressure
| Autor: | Rosilene V Ribeiro, Melinda Carrington, Rikeish R. Muralitharan, Michael E Nakai, Stephanie Yiallourou, Paul A. Gill, Francine Z. Marques, David M. Kaye, Geoffrey A. Head, Bruce R. Stevens, Jane G. Muir |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Ambulatory blood pressure Physiology Blood Pressure Butyrate 030204 cardiovascular system & hematology Gut flora Essential hypertension 03 medical and health sciences Immune system 0302 clinical medicine Internal Medicine medicine Humans Microbiome Receptor Aged biology business.industry Ruminococcus Blood Pressure Monitoring Ambulatory Middle Aged medicine.disease biology.organism_classification Gastrointestinal Microbiome Metabolic pathway 030104 developmental biology Blood pressure Case-Control Studies Female Essential Hypertension business Metabolic Networks and Pathways |
| Zdroj: | Hypertension. 78:804-815 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/hypertensionaha.121.17288 |
| Popis: | Recent evidence supports a role for the gut microbiota in hypertension, but whether ambulatory blood pressure is associated with gut microbiota and their metabolites remains unclear. We characterized the function of the gut microbiota, their metabolites and receptors in untreated human hypertensive participants in Australian metropolitan and regional areas. Ambulatory blood pressure, fecal microbiome predicted from 16S rRNA gene sequencing, plasma and fecal metabolites called short-chain fatty acid, and expression of their receptors were analyzed in 70 untreated and otherwise healthy participants from metropolitan and regional communities. Most normotensives were female (66%) compared with hypertensives (35%, P Acidaminococcus spp ., Eubacterium fissicatena, and Muribaculaceae were higher, while Ruminococcus and Eubacterium eligens were lower in hypertensives. Importantly, normotensive and essential hypertensive cohorts could be differentiated based on gut microbiome gene pathways and metabolites. Specifically, hypertensive participants exhibited higher plasma acetate and butyrate, but their immune cells expressed reduced levels of short-chain fatty acid-activated GPR43 (G-protein coupled receptor 43). In conclusion, gut microbial diversity did not change in essential hypertension, but we observed a significant shift in microbial gene pathways. Hypertensive subjects had lower levels of GPR43, putatively blunting their response to blood pressure-lowering metabolites. |
| Databáze: | OpenAIRE |
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