What is the impact of a rapid diagnostic E-test in the treatment of patients with Gram-negative bacteraemia?

Autor:	Manuel Canteras, Elisa García-Vázquez, Encarnación Moral-Escudero, Joaquín Gómez, Joaquín Ruiz, Alicia Hernández-Torres
Rok vydání:	2013
Předmět:	Microbiology (medical) Adult Male medicine.medical_specialty Time Factors Adolescent medicine.drug_class Antibiotics Bacteremia Microbial Sensitivity Tests Young Adult Antibiogram Internal medicine Gram-Negative Bacteria medicine Humans Prospective Studies Intensive care medicine Child Gram Aged Aged 80 and over Rapid diagnostic test General Immunology and Microbiology medicine.diagnostic_test business.industry Diagnostic test General Medicine Middle Aged Anti-Bacterial Agents Empirical treatment Infectious Diseases Blood Female business Gram-Negative Bacterial Infections
Zdroj:	Scandinavian journal of infectious diseases. 45(8)
ISSN:	1651-1980
Popis:	To evaluate the influence of a rapid diagnostic test (RDT) in antibiotic therapeutic decisions in non-paediatric patients with Gram-negative bacteraemia (GNB).A RDT consisting of a direct antibiogram was used on blood isolates of GNB. GNB were also identified and sensitivity tests were performed according to standard criteria. Information on empirical treatment was registered (T1), as well as the antibiotic administered once the results of the RDT were available (T2). Finally, we noted the ideal antibiotic that the infectious diseases specialist (IDS) would have prescribed (T3). The decision regarding T2 was always taken by the patient's physician or the physician on duty.A RDT was performed for 248 patients. The most frequently isolated bacterium was Escherichia coli (13% producing extended-spectrum beta-lactamase). T1 was considered appropriate in 74% and appropriate but optimizable in 43%. T2 was considered appropriate in 95%, appropriate but optimizable in 36%, and inappropriate in 5%. The cost of the optimizable treatment (T2) was € 2210, while the cost of the ideal treatment would have been € 416; the saving in antibiotic cost of 1 day of treatment would have been € 1694.Treatment prescribed by a non-IDS after a RDT was inappropriate in 5% and optimizable in 36%. It is our recommendation that information provided by a RDT should be interpreted by an IDS to make the information more beneficial both economically and 'ecologically'.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e5687e4a3dc1254b360efb1a73fa13 https://pubmed.ncbi.nlm.nih.gov/23596976 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.