Uncovering mechanisms of nuclear degradation in keratinocytes: A paradigm for nuclear degradation in other tissues
| Autor: | Ryan F.L. O'Shaughnessy, Clare Rogerson, Daniele Bergamaschi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Nucleophagy Keratinocytes Cell type nucleophagy reticulocytes denucleation Review 03 medical and health sciences chemistry.chemical_compound lens fibre cells nuclear degradation Organelle Gene expression medicine Animals Humans Cell Nucleus Chemistry Cell Biology DNA Cell biology 030104 developmental biology medicine.anatomical_structure Lens (anatomy) erythrocytes Nucleus Function (biology) enucleation |
| Zdroj: | Nucleus |
| ISSN: | 1949-1042 1949-1034 |
| Popis: | Eukaryotic nuclei are essential organelles, storing the majority of the cellular DNA, comprising the site of most DNA and RNA synthesis, controlling gene expression and therefore regulating cellular function. The majority of mammalian cells retain their nucleus throughout their lifetime, however, in three mammalian tissues the nucleus is entirely removed and its removal is essential for cell function. Lens fibre cells, erythroblasts and epidermal keratinocytes all lose their nucleus in the terminal differentiation pathways of these cell types. However, relatively little is known about the pathways that lead to complete nuclear removal and about how these pathways are regulated. In this review, we aim to discuss the current understanding of nuclear removal mechanisms in these three cell types and expand upon how recent studies into nuclear degradation in keratinocytes, an easily accessible experimental model, could contribute to a wider understanding of these molecular mechanisms in both health and pathology. |
| Databáze: | OpenAIRE |
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