Over-expression of MAGED4B increases cell migration and growth in oral squamous cell carcinoma and is associated with poor disease outcome
| Autor: | Chai Phei Gan, Rosnah Binti Zain, Mannil Thomas Abraham, Soo Hwang Teo, Stephen S. Prime, Christina A. Marsh, Chan Eng Chong, Vyomesh Patel, Sok Ching Cheong, J. Silvio Gutkind, Kue Peng Lim |
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| Přispěvatelé: | Chong, Chan Eng, Lim, Kue Peng, Gan, Chai Phei, Marsh, Christina A, Zain, Rosnah Binti, Abraham, Mannil Thomas, Prime, Stephen S, Teo, Soo-Hwang, Gutkind, J Silvio, Patel, Vyomesh, Cheong, Sok Ching |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment MAGED4B Melanoma antigens Oral Squamous Cell Carcinoma (OSCC) Migration Biology medicine.disease_cause migration Radiation Tolerance Cancer immunotherapy Antigens Neoplasm Cell Movement In vivo Cell Line Tumor Internal medicine medicine Humans Aged Cell Proliferation Melanoma-associated antigen Cell migration Middle Aged Prognosis In vitro Up-Regulation stomatognathic diseases MAGED4B melanoma antigens Drug Resistance Neoplasm Cell culture Apoptosis oral squamous cell carcinoma (OSCC) Lymphatic Metastasis Carcinoma Squamous Cell Female Mouth Neoplasms Cisplatin Carcinogenesis |
| Popis: | MAGE proteins have been shown to be good targets for cancer immunotherapy. We demonstrate that MAGED4B is over-expressed in more than 50 of Oral Squamous Cell Carcinoma (OSCC) tissues and the expression of MAGED4B is associated with lymph node metastasis and poor disease specific survival. OSCC cell lines that over-express MAGED4B promote migration in vitro, exhibit an increase in cell growth both in vitro and in vivo, and are more resistant to apoptosis compared to control cells. Our data suggest that MAGED4B over-expression is a driver in oral carcinogenesis and argues strongly that this protein may represent a potential therapeutic target in OSCC. This record was migrated from the OpenDepot repository service in June, 2017 before shutting down. |
| Databáze: | OpenAIRE |
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