| Autor: |
Francesco Ceppi, Giacomo Gotti, Anja Möricke, Daniela Silvestri, Fiona Poyer, Jana Lentes, Anke Bergmann, Jan Trka, Julia Alten, Sara Elitzur, Draga Barbaric, Barbara Buldini, Fabiola Dell'Acqua, Fabian Schumacher, Gabriella Casazza, Joelle Tchinda, Karin Nebral, Valentino Conter, Andishe Attarbaschi, Martin Schrappe |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
European Journal of Cancer. 175:120-124 |
| ISSN: |
0959-8049 |
| Popis: |
Near-tetraploidy-defined by DNA index 1.79-2.28 or 81-103 chromosomes-is a rare cytogenetic abnormality observed both in children and adults with T-cell acute lymphoblastic leukaemia (T-ALL) and its prognostic value is not yet determined.We report a retrospective study conducted in paediatric patients with newly diagnosed T-ALL treated in AIEOP-BFM ALL 2000 and 2009 studies. 31 near-tetraploid T-ALL patients (1.4%) are compared to T-ALL patients without near-tetraploidy.Near-tetraploid karyotype was associated with lower frequency of high-risk features: white blood cells count at diagnosis ≥100,000/μL (19.3% versus 41.0%, p-value lt; 0.001), PPR (13.3% versus 35.8%, p-value = 0.01) and minimal residual disease high-risk at the end of consolidation phase Induction B (4.03% versus 14.6%, p-value = 0.001). Complete remission was achieved at the end of induction phase (day 33) in 100% near-tetraploid T-ALL patients, compared to 93.2% T-ALL without near-tetraploidy.Overall, we found that near-tetraploid T-ALL in newly diagnosed paediatric patients is associated with low-risk presenting features, with favourable treatment response and outcome. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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